Evidence map›Paper›PMID 40050730›Full record

ArticleBMC genomics2025

High-resolution genetic and physical mapping reveals a peanut spotted wilt disease resistance locus, PSWDR-1, to Tomato spotted wilt virus (TSWV), within a recombination cold-spot on chromosome A01.

Dongliang Wu, Chuanzhi Zhao, Walid Korani, Ethan A Thompson, Hui Wang, Gaurav Agarwal, Jake C Fountain, Albert Culbreath, C Corley Holbrook, Xingjun Wang and 2 more

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Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2 citing papers in PubMed.

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12 authors.

Dongliang Wu *Department of Plant Pathology, University of Georgia, Tifton, GA, USA.
Chuanzhi Zhao *Department of Plant Pathology, University of Georgia, Tifton, GA, USA.
Walid Korani *HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Ethan A ThompsonDepartment of Plant Pathology, University of Georgia, Tifton, GA, USA.
Hui WangDepartment of Plant Pathology, University of Georgia, Tifton, GA, USA.
Gaurav AgarwalDepartment of Plant Pathology, University of Georgia, Tifton, GA, USA.
Jake C FountainDepartment of Plant Pathology, University of Georgia, Griffin, GA, USA.
Albert CulbreathUSDA-ARS Crop Genetics and Breeding Research Unit, Tifton, GA, USA.
C Corley HolbrookUSDA-ARS Crop Genetics and Breeding Research Unit, Tifton, GA, USA.
Xingjun WangInstitute of Crop Germplasm Resources, Shandong Academy of Agricultural Sciences, Shandong Provincial Key Laboratory of Crop Genetic Improvement, Ecology and Physiology, Jinan, China.
Josh P ClevengerHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA. jclevenger@hudsonalpha.org.
Baozhu GuoUSDA-ARS Crop Genetics and Breeding Research Unit, Tifton, GA, USA. baozhu.guo@usda.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeanut (Arachis hypogaea L.) is a vital global crop, frequently threatened by both abiotic and biotic stresses. Among the most damaging biotic stresses is Tomato spotted wilt virus (TSWV), which causes peanut spotted wilt disease resulting in significant yield loss. Developing TSWV-resistant cultivars is crucial to new cultivar release. Previous studies have used a subset of the "S" recombinant inbred line (RIL) population derived from SunOleic 97R and NC94022 and identified quantitative trait loci (QTLs) for resistance to TSWV. These studies utilized different genotyping techniques and found large consistent genomic regions on chromosome A01. The objective of this study was to fine map the QTL and identify candidate genes using the entire population of 352 RILs and high-density, high-quality peanut SNP arrays.

resultsWe used both versions of the peanut SNP arrays with five years of disease ratings, and successfully mapped the long-sought peanut spotted wilt disease resistance locus, PSWDR-1. QTL analyses identified two major QTLs, explaining 41.43% and 43.69% of the phenotypic variance within 3.6 cM and 0.28 cM intervals using the peanut Axiom_Arachis-v1 and Axiom_Arachis-v2 SNP arrays, respectively, on chromosome A01. These QTLs corresponded to 295 kb and 235 kb physical intervals. The unique overlap region of these two QTLs was 488 kb. A comparison of the genetic linkage map with the reference genome revealed a 1.3 Mb recombination "cold spot" (11.325-12.646 Mb) with only two recombination events of RIL-S1 and RIL-S17, which displayed contrasting phenotypes. Sequencing of these two recombinants confirmed the cold spot with only five SNPs detected within this region.

conclusionsThis study successfully identified a peanut spotted wilt disease resistance locus, PSWDR-1, on chromosome A01 within a recombination "cold spot". The PSWDR-1 locus contains three candidate genes, a TIR-NBS-LRR gene (Arahy.1PK53M), a glutamate receptor-like gene (Arahy.RI1BYW), and an MLO-like protein (Arahy.FX71XI). These findings provide a foundation for future functional studies to validate the roles of these candidate genes in resistance and application in breeding TSWV-resistant peanut cultivars.

Indexed as

ArachisChromosomes, PlantDisease ResistancePhysical Chromosome MappingPlant DiseasesRecombination, GeneticTospovirusChromosome MappingPolymorphism, Single NucleotideQuantitative Trait LociArachis hypogaeaLinkage and physical mappingPeanut spotted wilt disease resistance locusRecombination cold spotTSWV

Identifiers

PMID40050730
PMCPMC11887336

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