ArticleNature methods2025
DREDge: robust motion correction for high-density extracellular recordings across species.
Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
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- Density-based longitudinal neuron tracking in high-density electrophysiological recordings.Patterns (New York, N.Y.) · 2026Article
- Efficient and reproducible pipelines for spike sorting large-scale electrophysiology data.eLife · 2026Article
- KIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Tracking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Large-scale single-neuron recording in the human cortex using an ultra-flexible electrode array.Nature communications · 2026Article
- A transcriptomic axis aligns with in vivo functional dynamics in hippocampal inhibitory circuits.bioRxiv : the preprint server for biology · 2026Article
- CUSP: Complex spike sorting from multi-electrode array recordings with U-net sequence-to-sequence prediction.Journal of neuroscience methods · 2026Article
- Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings.Microsystems & nanoengineering · 2026Article
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- Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings.Neuron · 2025Article
- CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction.bioRxiv : the preprint server for biology · 2025Article
- Large-scale high-density brain-wide neural recording in nonhuman primates.Nature neuroscience · 2025Article
- Entering the era of deep single-cell proteomics.Nature methods · 2025Article
- Large scale, simultaneous, chronic neural recordings from multiple brain areas.bioRxiv : the preprint server for biology · 2024Article
- Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings.bioRxiv : the preprint server for biology · 2024Article
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Abstract
High-density microelectrode arrays have opened new possibilities for systems neuroscience, but brain motion relative to the array poses challenges for downstream analyses. We introduce DREDge (Decentralized Registration of Electrophysiology Data), a robust algorithm for the registration of noisy, nonstationary extracellular electrophysiology recordings. In addition to estimating motion from action potential data, DREDge enables automated, high-temporal-resolution motion tracking in local field potential data. In human intraoperative recordings, DREDge's local field potential-based tracking reliably recovered evoked potentials and single-unit spike sorting. In recordings of deep probe insertions in nonhuman primates, DREDge tracked motion across centimeters of tissue and several brain regions while mapping single-unit electrophysiological features. DREDge reliably improved motion correction in acute mouse recordings, especially in those made with a recent ultrahigh-density probe. Applying DREDge to recordings from chronic implantations in mice yielded stable motion tracking despite changes in neural activity between experimental sessions. These advances enable automated, scalable registration of electrophysiological data across species, probes and drift types, providing a foundation for downstream analyses of these rich datasets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.