Evidence map›Paper›PMID 40050652›Full record

ArticleNPJ Parkinson's disease2025

Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson's disease: analysis of two cohorts.

Xuemei Wang, Huimin Chen, Xinxin Ma, Huijing Liu, Dongdong Wu, Wei Du, Jing He, Shuhua Li, Haibo Chen, Tao Wu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xuemei Wang *Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Huimin Chen *Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Xinxin MaDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Huijing LiuDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Dongdong WuDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Wei DuDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Jing HeDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Shuhua LiDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Haibo ChenDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Tao WuCenter for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0002-9916-4253
Tao FengCenter for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. bxbkyjs@sina.com.ORCID http://orcid.org/0000-0002-8530-4622
Wen SuDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. suwenbjyy@163.com.ORCID http://orcid.org/0000-0002-2248-7361

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82271459Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) 7212031
6 · The paper itself

Abstract

Evidence regarding brain structural atrophy associated with Freezing of Gait (FOG) in Parkinson's disease (PD) is inconsistent. We analyzed cortical thickness and subcortical nuclei volumes using FreeSurfer in two large PD cohorts. In cohort 1 (N = 316), multivariate analyses identified reduced pallidum and ventral diencephalon (VDC) volumes as significantly associated with FOG presence. Validation in the Parkinson's Progression Markers Initiative (PPMI) cohort (cohort 2, N = 94) demonstrated that decreased VDC volume at four-year follow-up independently predicted higher FOG risk, improving the predictive model's accuracy when combined with PIGD score, CSF Aβ42, and caudate DAT uptake (AUC 0.760; Δχ

Identifiers

PMID40050652
PMCPMC11885666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.