Evidence map›Paper›PMID 40050617›Full record

ArticleNature communications2025

Deep learning-driven pulmonary artery and vein segmentation reveals demography-associated vasculature anatomical differences.

Yuetan Chu, Gongning Luo, Longxi Zhou, Shaodong Cao, Guolin Ma, Xianglin Meng, Juexiao Zhou, Changchun Yang, Dexuan Xie, Dan Mu and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  4. Artificial intelligence in respiratory medicine: From diagnosis to treatment and future directions.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuetan Chu *Center of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0003-1729-831X
Gongning Luo *Center of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia. gongning.luo@kaust.edu.sa.ORCID http://orcid.org/0000-0003-3662-0335
Longxi ZhouCenter of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0003-0116-9361
Shaodong CaoDepartment of Radiology, The Fourth Hospital of Harbin Medical University, Harbin, China.
Guolin MaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, China.
Xianglin MengDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID http://orcid.org/0000-0001-5091-3260
Juexiao ZhouCenter of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0002-6739-6236
Changchun YangCenter of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0002-7932-1952
Dexuan XieDepartment of Computer Tomography, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Dan MuDepartment of Radiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Ricardo HenaoComputer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Gianluca SettiElectrical and Computer Engineering Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia. gianluca.setti@kaust.edu.sa.ORCID http://orcid.org/0000-0002-2496-1856
Xigang XiaoDepartment of Computer Tomography, The First Affiliated Hospital of Harbin Medical University, Harbin, China. xxgct_417@126.com.ORCID http://orcid.org/0000-0002-2795-9823
Lianming WuDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wlmssmu@126.com.
Zhaowen QiuCollege of Computer and Control Engineering, Northeast Forestry University, Harbin, China. qiuzw@nefu.edu.cn.ORCID http://orcid.org/0000-0001-5292-0333
Xin GaoCenter of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia. xin.gao@kaust.edu.sa.ORCID http://orcid.org/0000-0002-7108-3574

Funding

King Abdullah University of Science and Technology (KAUST) Center of Excellence for Smart Health (KCSH), under award number 5932King Abdullah University of Science and Technology (KAUST) Center of Excellence on Generative AI, under award number 5940
6 · The paper itself

Abstract

Pulmonary artery-vein segmentation is critical for disease diagnosis and surgical planning. Traditional methods rely on Computed Tomography Pulmonary Angiography (CTPA), which requires contrast agents with potential health risks. Non-contrast CT, a safer and more widely available approach, however, has long been considered impossible for this task. Here we propose High-abundant Pulmonary Artery-vein Segmentation (HiPaS), enabling accurate segmentation across both non-contrast CT and CTPA at multiple resolutions. HiPaS integrates spatial normalization with an iterative segmentation strategy, leveraging lower-level vessel segmentations as priors for higher-level segmentations. Trained on a multi-center dataset comprising 1073 CT volumes with manual annotations, HiPaS achieves superior performance (dice score: 91.8%, sensitivity: 98.0%) and demonstrates non-inferiority on non-contrast CT compared to CTPA. Furthermore, HiPaS enables large-scale analysis of 11,784 participants, revealing associations between vessel abundance and sex, age, and diseases, under lung-volume control. HiPaS represents a promising, non-invasive approach for clinical diagnostics and anatomical research.

Indexed as

Deep LearningPulmonary ArteryPulmonary VeinsAdultAgedComputed Tomography AngiographyFemaleHumansLungMaleMiddle AgedTomography, X-Ray Computed

Identifiers

PMID40050617
PMCPMC11885638

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.