ArticleCommunications biology2025
Neurophysiological insights into catecholamine-dependent tDCS modulation of cognitive control.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of transcranial electrical stimulation combined with dual-task training in stroke, mild cognitive impairment and Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in human neuroscience · 2025Pooled it
- Neurophysiological insights into catecholamine-dependent tDCS modulation of cognitive control.Communications biology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Goal-directed behavior requires resolving both consciously and subconsciously induced response conflicts. Neuronal gain control, which enhances processing efficacy, is crucial for conflict resolution and can be increased through pharmacological or brain stimulation interventions, though it faces inherent physical limits. This study examined the effects of anodal transcranial direct current stimulation (atDCS) and methylphenidate (MPH) on conflict processing. Healthy adults (n = 105) performed a flanker task, with electroencephalography (EEG) used to assess alpha and theta band activity (ABA, TBA). Results showed that combining atDCS with MPH enhanced cognitive control and reduced response conflicts more effectively than atDCS alone, particularly when both conflict types co-occurred. Both atDCS and atDCS + MPH exhibited similar task-induced ABA and TBA modulations in the (pre)supplementary motor area, indicating heightened gain control. Overlapping neuroanatomical effects in mid-superior frontal areas suggest that atDCS and MPH share a common neuronal mechanism of gain control, especially in high-conflict/-demand situations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.