Evidence map›Paper›PMID 40050502›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025

Development of self-report measures of physical, mental, and emotional fatigability: the michigan fatigability index (MIFI).

Anna L Kratz, Noelle E Carlozzi, Susan L Murphy, Tiffany J Braley, Daniel Whibley, David A Williams, Nora E Fritz, Michael Kallen

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Anna L KratzDepartment of Physical Medicine and Rehabilitation, University of Michigan, 2800 Plymouth Road, North Campus Research Complex, B016-G017W, Ann Arbor, MI, USA. alkratz@med.umich.edu.ORCID http://orcid.org/0000-0002-3664-3898
Noelle E CarlozziDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-0439-9429
Susan L MurphyDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7924-0012
Tiffany J BraleyDepartment of Neurology, Divisions of MS/Neuroimmunology for Multiple Sclerosis and Sleep Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-0680-7828
Daniel WhibleyDepartment of Physical Medicine and Rehabilitation, University of Michigan, 2800 Plymouth Road, North Campus Research Complex, B016-G017W, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7131-7158
David A WilliamsDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5052-4895
Nora E FritzDepartments of Health Care Sciences and Neurology, Wayne State University School of Medicine, Detroit, MI, USA.ORCID http://orcid.org/0000-0002-4548-1077
Michael KallenFeinberg School of Medicine, Northwestern Medicine, Chicago, IL, USA.

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Development of a conceptual model of subjective physical and mental fatigability: the MI-FI studyR21AG053186 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KRATZ, ANNA LOUISE · 2016 to 2017
$426k
NIA NIH HHS AG024824NIA NIH HHS P30 AG024824NIA NIH HHS R21 AG053186NIA NIH HHS R21AG053186
6 · The paper itself

Abstract

purposeTo develop item banks and static short-forms for a patient reported outcome measure of perceived physical, mental, and emotional fatigability-the Michigan Fatigability Index (MIFI).

methodsBuilding on earlier qualitative work, this study utilized cognitive interviews in samples representing the general adult population across the lifespan, people with multiple sclerosis (MS), or people with fibromyalgia (FM) to develop initial item pools. A nationwide cross-sectional survey study in MS and FM samples was used to field test items to develop item banks.

resultsExploratory and confirmatory factors analyses indicated single underlying dimensions for each of the MIFI subdomains, and a graded response model (GRM) supported item fit of 42, 28, and 23 items to the physical, mental, and emotional fatigability items banks, respectively. Differential item functioning was not detected for age, condition (FM vs. MS), education level, ethnicity, race, or sex. Expert review and GRM calibration data was used to inform the selection of three 6-item short forms that assess physical, mental, and emotional fatigability and to program associated computer adaptive tests.

conclusionThe MIFI shows initial evidence of good psychometric properties. Users can administer the MIFI as a static short form and efforts are underway to provide access to the measure as a computer adaptive test. T-Score scale conversion allows comparison of individual scores to a normative clinical sample with a wide range of fatigability.

Indexed as

FatigueFibromyalgiaMultiple SclerosisQuality of LifeSelf ReportAdultAgedCross-Sectional StudiesFemaleHumansMaleMichiganMiddle AgedPsychometricsSurveys and QuestionnairesAgingFatigabilityFibromyalgiaMultiple sclerosisPatient reported outcome measures

Identifiers

PMID40050502
PMCPMC12687931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.