Evidence map›Paper›PMID 40050482›Full record

SynthesisSpinal cord2025

Treatments of fatigue after spinal cord injury: a systematic review and meta-analysis.

Carlos Leonardo Cano-Herrera, Gita Manhas, Matthew Querée, Bob Hoogenes, Emma A Bateman, Eldon Loh, William C Miller, W Ben Mortenson, Andrea Townson, Janice J Eng and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Spinal cord, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carlos Leonardo Cano-HerreraDepartment of Physical Therapy, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-5702-8918
Gita ManhasFaculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Matthew QueréeDepartment of Physical Therapy, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-2390-1496
Bob HoogenesGGZ inGeest Mental Healthcare Services, Amsterdam, Netherlands.
Emma A BatemanParkwood Institute Research, Lawson Health Research Institute, London, ON, Canada.
Eldon LohParkwood Institute Research, Lawson Health Research Institute, London, ON, Canada.ORCID 0000-0001-5063-4827
William C MillerCentre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
W Ben MortensonCentre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-0183-6163
Andrea TownsonCentre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.ORCID 0000-0001-6711-6145
Janice J EngDepartment of Physical Therapy, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada. janice.eng@ubc.ca.ORCID 0000-0002-2093-0788
SCIRE Research Team

Funding

Rick Hansen Institute (Institut Rick Hansen) N/A
6 · The paper itself

Abstract

STUDY

designSystematic Review and Meta-analysis.

settingCanada.

objectivesFatigue is one of the most common consequences of spinal cord injury (SCI). In this systematic review and meta-analysis, we examined interventions for fatigue in SCI and evaluated their effectiveness.

methodsMEDLINE, EMBASE, CINAHL, and PsycINFO databases were searched up to January 2024 inclusive. Randomized controlled trials (RCTs) that assessed any intervention for at least one fatigue outcome in people with SCI were included. Study quality was assessed using the Cochrane Risk of Bias Tool.

resultsInitial screening identified 282 studies from which six RCTs were included in the review (N = 249). One study found that moderate-intensity arm-crank exercise significantly improved fatigue compared to a control group (p = 0.036) with a large effect size (standard mean difference [SMD] = 1.05; 95% confidence interval [CI], 0.10-2.00). Two studies assessing behavioral interventions found a moderate effect on fatigue (SMD = 0.46; 95% CI, -0.00-0.92; p = 0.05). Two studies did not find an effect of massage therapy on fatigue (SMD = 0.06; 95% CI, -0.38-0.50; p = 0.80). The risk of bias was classified as High for all but two of the RCTs.

conclusionsThese findings suggest that exercise and behavioral interventions promoting an active lifestyle may have a positive effect on fatigue. More research with larger sample sizes, including controls for co-morbid conditions like pain and depression, is needed to establish evidence-based treatments for reducing fatigue in people with SCI.

Indexed as

Exercise TherapyFatigueSpinal Cord InjuriesHumansRandomized Controlled Trials as Topic

Identifiers

PMID40050482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.