Evidence map›Paper›PMID 40050454›Full record

ArticleEuropean radiology2025

Recurrent laryngeal nerve thermal injury in radiofrequency ablation for papillary thyroid carcinoma and related risk factors: a prospective large cohort study.

Qing Hua, YanYan Song, Wei Zhou, ZhenHua Liu, Lu Zhang, Ying Zhu, LiMei Lai, Yat Hin Yeung, Ning Li, WeiWei Zhan and 4 more

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Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qing Hua *Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China.
YanYan Song *Department of Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, 227 Chongqing South Road, 200025, Shanghai, China.
Wei ZhouDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China.
ZhenHua LiuDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China.
Lu ZhangDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China.
Ying ZhuDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China.
LiMei LaiDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China.
Yat Hin YeungDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China.
Ning LiDepartment of Ultrasound, Anning First People's Hospital, No.2 Ganghenan Road, 650330, Kunming, Yunnan Province, China.
WeiWei ZhanDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China.
YiJie DongDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. dongyiyin@126.com.
ShuJun XiaDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. xiashu_jun@126.com.
JianQiao ZhouDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. zhousu30@126.com.ORCID http://orcid.org/0000-0002-0964-8407
Chinese Ablation Alliance for Thyroid and Cervical Lymph Nodes

Funding

National Natural Science Foundation of China 82071928Program of Shanghai Academic/Technology Research Leader 23XD1401300
6 · The paper itself

Abstract

objectiveTo establish a prediction model for recurrent laryngeal nerve thermal injury (RLNTI) in radiofrequency ablation (RFA) of papillary thyroid carcinoma (PTC). MATERIALS AND

methodsThis prospective study was conducted at a single center from July 2016 to September 2022. Patients diagnosed with PTC and received US-RFA by different interventional therapy groups were enrolled, and classified as derivation cohort and validation cohort based on therapy groups. The logistic regression analysis was used in derivation cohort to develop the model and internal and external validation was performed in derivation and validation cohort respectively.

resultsThe derivation cohort included 1632 patients (mean age, 40 years, ±11 (standard deviation), 1300 female), and the validation cohort comprised 755 patients (mean age, 38 years, ±11 (standard deviation), 584 female). Three variables were independently associated with RLNTI: the minimum distance from tumor to tracheoesophageal groove (TEG-D) ≤ 2.95 mm (odds ratio, 8.179; p < 0.0001), tumor posterior location (odds ratio, 3.849; p = 0.0008) and ablation energy > 0.695 kcal (odds ratio, 4.537; p < 0.0001). The area under the receiver operating characteristic curve (AUC) of the model in the derivation cohort, validation cohort, and total group were 0.877 (95% CI: 0.845, 0.910), 0.901 (95% CI: 0.835, 0.967) and 0.886 (95% CI: 0.85, 0.915) respectively. The calibration plot and Hosmer-Lemeshow test demonstrated a good fit (χ² = 3.49, p = 0.321).

conclusionThe prediction model of RLNTI was derived based on TEG-D, tumor posterior location, and ablation energy and exhibited good discrimination and calibration abilities. KEY POINTS: Question Recurrent laryngeal nerve thermal injury (RLNTI) is a major complication of radiofrequency ablation (RFA) for papillary thyroid carcinoma (PTC), while related risk factors are unclear. Findings The minimum distance from tumor to tracheoesophageal groove ≤ 2.95 mm, tumor posterior location, and ablation energy > 0.695 kcal are factors independently associated with RLNTI. Clinical relevance This study developed a simple prediction model with good discrimination and calibration abilities, which provided interventional radiologists an evidence-based method to predict RLNTI and thereby reduce the incidence of RLNTI in RFA of PTC.

Indexed as

Radiofrequency AblationRecurrent Laryngeal Nerve InjuriesThyroid Cancer, PapillaryThyroid NeoplasmsAdultCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsPapillary thyroid carcinomaRadiofrequency ablationRecurrent laryngeal nerve thermal injuryUltrasound

Identifiers

PMID40050454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.