ArticleArchives of toxicology2025
Application of in silico methods to predict the acute toxicity of bicyclic organophosphorus compounds as potential chemical weapon.
Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- In Silico Forensic Toxicology: Is It Feasible?Toxics · 2025Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bicyclic organophosphorus compounds (BOPCs), including flame retardants and plasticisers, are widely used in industrial applications because of their thermal stability and resistance to degradation. However, their unique structural properties and mechanisms of toxicity raise concerns regarding their potential misuse. Unlike classical organophosphorus compounds that inhibit acetylcholinesterase, BOPCs exert toxicity by antagonising gamma-aminobutyric acid receptors, resulting in severe neurotoxic effects, including convulsions and seizures. This underscores the urgent need to prioritise predictive toxicity studies on these compounds as part of a national defence strategy. The present study represents the first extensive application of in silico toxicological approaches to investigate the acute toxicity of a BOPC dataset (n = 18) utilising advanced in silico tools, such as QSAR models and probabilistic software/platforms, to predict acute oral toxicity in rats. All the investigated BOPCs are highly acutely toxic, judging from LD
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Registered trials
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