ArticleJournal of exposure science & environmental epidemiology2025
Transplacental transfer efficiency of perfluoroalkyl substances (PFAS) after long-term exposure to highly contaminated drinking water: a study in the Ronneby Mother-Child Cohort.
Article in Journal of exposure science & environmental epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women-temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations.Environmental health : a global access science source · 2025Trial
- Tracing PFAS Transfer from Mother to the Fetoplacental Unit: Insights from Trimester-Specific Maternal Serum Profiles.bioRxiv : the preprint server for biology · 2026Article
- Current Status of Per- and Poly-Fluoroalkyl Substances (PFAS) Exposure on Lung Cell Biology and Pulmonary Outcomes along Human Health Risk Assessment Steps.Current allergy and asthma reports · 2026Review
- New Mechanistic Evidence for Perfluorodecanoic Acid (PFDA) Teratogenicity via CYP26A1-Mediated Retinoic Acid Metabolism and Signaling.Chemical research in toxicology · 2026Article
- Natural variation in transplacental transfer efficiency exposes distinct transcriptional network architectures of PFAS effects on birth weight and gestational age.bioRxiv : the preprint server for biology · 2026Article
- Exposure to per- and polyfluoroalkyl substances during fetal development and risk of testicular germ cell cancer in adulthood.Environment international · 2025Article
- PFAS Exposure, Mental Health, and Environmental Justice in the United States: Impacts on Marginalized Communities.International journal of environmental research and public health · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerfluoroalkyl substances (PFAS) are stable chemicals used in various applications. PFAS exposure has been associated with lower birth weight and immunological effects in children, and limited evidence further suggests adverse neurodevelopmental effects. Previous studies show that PFAS cross the placental barrier during pregnancy leading to prenatal exposure of the fetus. Research on the transplacental transfer efficiency (TTE) of PFAS in highly exposed populations is lacking.
objectiveThis study aimed to estimate the TTE of eight PFAS and three perfluorooctane sulfonic acid (PFOS) isomers in a birth cohort with a wide range of PFAS exposures and to investigate if maternal exposure level impacted the estimated TTE.
methodsThe participants, most of whom had been exposed to PFAS-contaminated municipal drinking water, were recruited between 2015 and 2020 after the end of exposure. We collected maternal serum samples during pregnancy and at delivery, as well as umbilical cord serum. Serum samples were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). TTE was estimated as the ratio of the PFAS concentration in cord serum to maternal serum. We used generalized additive mixed models accounting for maternal characteristics to assess if maternal exposure level (i.e., high, intermediate, or background) modified the estimated TTE.
resultsThe study included 200 dyads with matched cord and maternal serum samples. The exposure profile was dominated by perfluorohexane sulfonic acid (PFHxS) and PFOS. We observed the highest overall transfer efficiency for PFHxS (median TTE: 0.68) and the lowest for the n-PFOS isomer (median TTE: 0.33). Higher TTEs were observed for PFHxS and PFOS (total and isomers) in background-exposed dyads. IMPACT STATEMENT: In a birth cohort with a wide range of exposures to primarily PFOS and PFHxS from contaminated drinking water, we found that the transplacental transfer efficiencies (TTE) of eight PFAS and three PFOS isomers were of considerable magnitude. The highest TTE were observed for PFOA and PFHxS, and for branched PFOS isomers compared with linear. Although we observed slightly lower TTE in mother-child dyads with high and intermediate exposures compared with dyads with background levels of exposure, the considerable TTE in highly exposed mothers implies high absolute prenatal exposure in children in contaminated areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.