Evidence map›Paper›PMID 40050377›Full record

ArticleScientific reports2025

Creating a retinal image database to develop an automated screening tool for diabetic retinopathy in India.

Ramachandran Rajalakshmi, Thyparambil Aravindakshan PramodKumar, Ashis Kumar Dhara, Geetha Kumar, Naziya Gulnaaz, Shramana Dey, Sourav Basak, B Uma Shankar, Raka Goswami, Raja Mohammed and 11 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ramachandran Rajalakshmi *Department of Ophthalmology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, 6, Conran Smith Road Gopalapuram, Chennai, 600 086, India. drraj@drmohans.com.
Thyparambil Aravindakshan PramodKumar *Department of Research Operations, Data Management and Diabetes Complications, Madras Diabetes Research Foundation, Chennai, India.
Ashis Kumar DharaDepartment of Electrical Engineering, National Institute of Technology Durgapur, Durgapur, India.
Geetha KumarDepartment of Vitreo-Retina, Vision Research Foundation, Sankara Netralaya, Chennai, India.
Naziya GulnaazDepartment of Research Operations, Data Management and Diabetes Complications, Madras Diabetes Research Foundation, Chennai, India.
Shramana DeyMachine Intelligence Unit, Indian Statistical Institute, Kolkata, India.
Sourav BasakDepartment of Electrical Engineering, National Institute of Technology Durgapur, Durgapur, India.
B Uma ShankarMachine Intelligence Unit, Indian Statistical Institute, Kolkata, India.
Raka GoswamiDepartment of Electrical Engineering, National Institute of Technology Durgapur, Durgapur, India.
Raja MohammedDepartment of Ophthalmology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, 6, Conran Smith Road Gopalapuram, Chennai, 600 086, India.
Suchetha ManikandanCentre for Healthcare Advancements, Innovation and Research, Vellore Institute of Technology, Chennai, India.
Sushmita MitraMachine Intelligence Unit, Indian Statistical Institute, Kolkata, India.
Harsimran ThethiPES University, Bangalore, India.
Saravanan JebaraniDepartment of Research Operations, Data Management and Diabetes Complications, Madras Diabetes Research Foundation, Chennai, India.
Sinnakaruppan MathavanDepartment of Vitreo-Retina, Vision Research Foundation, Sankara Netralaya, Chennai, India.
Tamilselvi SarveswaranCentre for Healthcare Advancements, Innovation and Research, Vellore Institute of Technology, Chennai, India.
Ranjit Mohan AnjanaDepartment of Diabetology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India.
Viswanathan MohanDepartment of Diabetology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India.
Sambuddha GhoshDepartment of Ophthalmology, Calcutta National Medical College, Kolkata, India.
Tushar Kanti BeraDepartment of Electrical Engineering, National Institute of Technology Durgapur, Durgapur, India.
Rajiv RamanDepartment of Vitreo-Retina, Vision Research Foundation, Sankara Netralaya, Chennai, India.

Funding

Department of Biotechnology , Ministry of Science and Technology (DBT) BT/PR33185/AI/133/13/2019
6 · The paper itself

Abstract

Diabetic retinopathy (DR), a prevalent microvascular complication of diabetes, is the fifth leading cause of blindness worldwide. Given the critical nature of the disease, it is paramount that individuals with diabetes undergo annual screening for early and timely detection of DR, facilitating prompt ophthalmic assessment and intervention. However, screening for DR, which involves assessing visual acuity and retinal examination through ophthalmoscopy or retinal photography, presents a significant global challenge due to the massive volume of individuals requiring annual reviews. To counter this challenge, there has been an increasing interest in the potential of artificial intelligence (AI) tools for automated diagnosis of DR. The AI tools primarily utilize deep learning (DL) techniques and are tailored to analyse extensive medical image data and provide diagnostic outputs, essentially streamline the DR screening process. However, the development of such AI tools requires access to a comprehensive retinal image database with a plethora of high-resolution fundus images from various cameras, covering all DR lesions. Additionally, the accurate training of these AI algorithms necessitates skilled professionals, such as optometrists or ophthalmologists, to provide reliable ground truths that ensure the precision of the diagnostic outputs. To address these prerequisites, we have initiated a study involving multiple institutions to establish a large-scale online 'Retinal Image Database' in India, aiming to contribute significantly to DR research. This paper delineates the methodology employed for this significant undertaking, detailing the steps taken to create the large retinal image database, as well as the framework for developing a cost-effective, robust AI-based DR diagnostic tool. Our work is expected to mark a significant stride in DR detection and management, promising a more efficient and scalable solution for tackling this global health challenge.

Indexed as

Databases, FactualDiabetic RetinopathyRetinaAlgorithmsArtificial IntelligenceDeep LearningHumansImage Processing, Computer-AssistedIndiaMass ScreeningArtificial intelligenceDeep learningDiabetic retinopathyFundus photographsGrading platformRetinal image databaseRetinal images

Identifiers

PMID40050377
PMCPMC11885578

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.