Evidence map›Paper›PMID 40050371›Full record

ArticleScientific reports2025

Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan.

Wafa Naeem, Fouzia Nawab, Muhammad Tahir Sarwar, Ali Talha Khalil, Dalia Ali Gaber, Hilal Ahmad, Muhammad Fazeel, Mohammed Alorini, Ishtiaq Ahmad Khan, Muhammad Irfan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Mutational insights andFrontiers in bioinformatics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wafa NaeemInstitute of Basic Medical Sciences, Khyber Medical University, Phase V, Peshawar, 25000, Pakistan.
Fouzia NawabInstitute of Basic Medical Sciences, Khyber Medical University, Phase V, Peshawar, 25000, Pakistan.
Muhammad Tahir SarwarInstitute of Basic Medical Sciences, Khyber Medical University, Phase V, Peshawar, 25000, Pakistan.
Ali Talha KhalilDepartment of Pathology, Lady Reading Hospital Medical Teaching Institution (LRH-MTI), Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan. alitalha.khalil@lrh.edu.pk.
Dalia Ali GaberMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Hilal AhmadInstitute of Basic Medical Sciences, Khyber Medical University, Phase V, Peshawar, 25000, Pakistan.
Muhammad FazeelPhelma Grenoble INP, Université Grenoble Alpes, Grenoble, France.
Mohammed AloriniDepartment of Pathology, College of Medicine, Qassim University, Unaizah, Saudi Arabia.
Ishtiaq Ahmad KhanJamil-Ur-Rahman Center for Genome Research, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Muhammad IrfanJamil-Ur-Rahman Center for Genome Research, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Muslim KhanDepartment of Oral and Maxillofacial Surgery, Khyber College of Dentistry, Peshawar, Pakistan.
Syed Ali KhurramSchool of Clinical Dentistry, Faulty of Health, University of Sheffield, Sheffield, S10 2TA, UK. s.a.khurram@sheffield.ac.uk.
Asif AliDepartment of Pathology, College of Medicine, Qassim University, Unaizah, Saudi Arabia. draliasif7@gmail.com.

Funding

Higher Education Commission, Pakistan ICRG-46.
6 · The paper itself

Abstract

Herein, we reported mutations in five DNA Damage Repair (DDR) i.e., TP53, ATR, ATM, CHEK1 and CHEK2 involved in OSCC using NG-WES and their analysis using bioinformatics tools. Out of 42 identified mutations, 16.7% are reported for the 1st time. A total of 28 nonsynonymous SNVs are identified. TP53 harbored the highest number of mutations followed by ATM, ATR, CHEK1 and CHEK2. Nine mutations (TP53

Indexed as

Carcinoma, Squamous CellDNA DamageDNA RepairMouth NeoplasmsMutationAtaxia Telangiectasia Mutated ProteinsCheckpoint Kinase 1Checkpoint Kinase 2Computational BiologyFemaleHumansMaleMiddle AgedPakistanTumor Suppressor Protein p53Ataxia Telangiectasia Mutated ProteinsCheckpoint Kinase 1Checkpoint Kinase 2CHEK1 protein, humanCHEK2 protein, humanTP53 protein, humanTumor Suppressor Protein p53BioinformaticsBiomarkerNGSOncogenomicsOral cancerPashtun

Identifiers

PMID40050371
PMCPMC11885471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.