ArticleScientific reports2025
Developmental and toxicological effects of butylated hydroxytoluene metabolites on zebrafish larvae.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury.Materials today. Bio · 2025Article
- Butylated hydroxytoluene (BHT) induces zebrafish spinal cord defects and scoliosis by inhibiting the hedgehog pathway.Scientific reports · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Butylated hydroxytoluene (BHT) is among the most widely used synthetic phenolic antioxidants. However, BHT and its metabolites have been detected in aquatic ecosystems, posing potential risks to aquatic organisms. The present study aimed to investigate the effects of BHT metabolites on embryonic development in zebrafish. To this end, embryos were exposed to BHT metabolites, including 3,5-di-tert-butyl-4 hydroxybenzaldehyde (BHT-CHO), 2,6-di-tert-butyl-4-(hydroxymethyl) phenol (BHT-OH), 3,5-di-tert-butyl-4 hydroxybenzoic acid (BHT-COOH), 2,6-di-tert-butyl-P-benzoquinone (BHT-Q), and 2,6-di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dien-1-one (BHT-quinol), from 1-120 h post-fertilization (hpf). BHT-CHO, -OH, -COOH, -Q, and -quinol were toxic to zebrafish larvae with 96 h LC
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