Evidence map›Paper›PMID 40050322›Full record

ArticleScientific data2025

Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

Zsuzsanna Ament, Naruchorn Kijpaisalratana, Varun M Bhave, Catharine A Couch, Ana-Lucia Garcia Guarniz, Amit Patki, Mary Cushman, Suzanne E Judd, M Ryan Irvin, W Taylor Kimberly

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zsuzsanna AmentCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0316-4348
Naruchorn KijpaisalratanaCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Varun M BhaveHarvard Medical School, Boston, MA, USA.
Catharine A CouchDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Ana-Lucia Garcia GuarnizCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Amit PatkiDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-7871-6143
Suzanne E JuddDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
M Ryan IrvinDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
W Taylor KimberlyCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. wtkimberly@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-2519-8530

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Gut microbiome-related metabolites and cognitive impairmentR01AG089361 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI William Taylor Kimberly · 2024 to 2026
$3.9M
Metabolomic predictors of stroke in REGARDSR01NS099209 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI KIMBERLY, WILLIAM TAYLOR · 2017 to 2021
$2.4M
Shared and novel contributors to risk of stroke and stroke recurrence in a multiethnic population – the role of social determinants of health, genetics, and epigeneticsR01NS136542 · NINDS · UNIVERSITY OF VIRGINIA · PI HSU, FANG-CHI, KEENE, KEITH L · 2024 to 2025
$1.2M
NIA NIH HHS R01 AG089361NINDS NIH HHS R01 NS099209NINDS NIH HHS R01 NS136542NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. This longitudinal study investigates health outcomes with a focus on stroke disparities across the United States, particularly in the Southeastern "Stroke Belt," where stroke risk and mortality are 2-4 times higher in the Black population. The REGARDS study recruited 30,239 Black and White participants aged 45 years or older. This dataset includes 2,377 baseline plasma samples collected between 2003 and 2007 from a stroke case-cohort sub-study, with 1,056 randomly selected cohort participants and 1,321 stroke cases. The resulting data provides a resource for investigating metabolic profiles and their potential implications for health outcomes and disparities.

Indexed as

MetabolomicsStrokeAgedBlack or African AmericanFemaleHumansLongitudinal StudiesMaleMiddle AgedUnited StatesWhite

Identifiers

PMID40050322
PMCPMC11885657

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.