ArticleACS applied materials & interfaces2025
Cancer Photodynamic Therapy Enabled by Water-Soluble Chlorophyll Protein.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Natural Product-Based Upconversion-Downshifting Photosensitizers in Photodynamic Therapy.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Exploring Microalgae as a Novel Resource for Hepatocellular Carcinoma Therapy.Molecules (Basel, Switzerland) · 2026Review
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Authors and funding
9 authors.
Funding
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Abstract
Photodynamic therapy (PDT) has been utilized to treat various malignant cancers for more than a century. However, many photosensitizers (e.g., derivatives of porphyrins, chlorins, etc.) central to PDT are still suffering from limitations such as water insolubility, dark toxicity, photo/thermal-instability, difficult synthesis/preparation, and poor tumor selectivity. Numerous effective strategies include designing new synthetic photosensitizers by exploiting heavy atom effect, aggregation-induced emission effect (AIE), and electronic/energy effects (donor-acceptor, and Förster resonance energy transfer: FRET), and the linkage of activatable and targeting molecules has been developed to address one or more of these limitations. However, these structural modifications of photosensitizing organic molecules are synthetically challenging and unpredictable in terms of efficacy versus toxicity. Herein, we report a new and simple strategy for effective PDT by combining natural spinach-derived chlorophylls (photosensitizer) with natural water-soluble chlorophyll proteins (WSCPs) derived originally from plants and produced heterologously by bacteria (
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