Evidence map›Paper›PMID 40050026›Full record

ArticleBMJ paediatrics open2025

Single-centre comparative study of in vitro fertilisation and naturally conceived babies in Indonesia.

Putri Maharani Tristanita Marsubrin, Kanya Lalitya Jayanimitta Sugiyarto, Jessica Sylvania Oswari, Rinawati Rohsiswatmo, Rosalina Dewi Roeslani, Adhi Teguh Perma Iskandar, Distyayu Sukarja, Muhamad Azharry Rully Sjahrullah, Ahmad Kautsar, Raden Muharam

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Putri Maharani Tristanita MarsubrinDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia putristanita2806@yahoo.com.ORCID http://orcid.org/0000-0002-5680-6244
Kanya Lalitya Jayanimitta SugiyartoDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.
Jessica Sylvania OswariDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.
Rinawati RohsiswatmoDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.
Rosalina Dewi RoeslaniDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.
Adhi Teguh Perma IskandarDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.
Distyayu SukarjaDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.
Muhamad Azharry Rully SjahrullahDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.
Ahmad KautsarDepartment of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.
Raden MuharamDepartment of Obstetrics and Gynecology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn vitro fertilisation (IVF) offers a solution for infertility but poses increased obstetrical and perinatal risks, including higher rates of preterm birth, low birth weight and congenital anomalies. Particularly, IVF-related multiple pregnancies face significantly higher risks for preterm birth and prolonged hospital stays. This study compares neonatal outcomes between IVF and natural conception, as well as between singleton and IVF-related multiple pregnancies over the past decade.

methodThis retrospective study reviewed the medical records of babies born at Cipto Mangunkusumo Kencana Hospital from 2013 to 2023. Neonatal morbidities (hypothermia, hypoglycaemia, respiratory distress, circulation problems, sepsis, congenital anomalies, all stages of intraventricular haemorrhage and retinopathy of prematurity of all babies, neonatal intensive care unit (NICU) admission and length of stay) were dependent variables, with the mode of conception as the independent variable.

resultOf 609 subjects, 169 were IVF conceptions and 435 natural conceptions. The IVF group had higher rates of prematurity (27.8% vs 10.8%, p<0.001), multiple conceptions (37.9% vs 7.4%, p<0.001) and older maternal age (35 vs 30 years, p<0.001). Prematurity in the IVF group had an increased rate of respiratory distress (18.9% vs 12.6%, p=0.05), higher NICU admission rates (13.6% vs 3.2%, p<0.001) and longer hospital stays.

conclusionIVF pregnancies had higher risks of prematurity and respiratory distress, necessitating personalised antenatal care and close monitoring to optimise neonatal outcomes.

Indexed as

Fertilization in VitroPremature BirthAdultFemaleHumansIndonesiaInfant, NewbornIntensive Care Units, NeonatalLength of StayMalePregnancyPregnancy, MultiplePregnancy OutcomeRetrospective StudiesNeonatology

Identifiers

PMID40050026
PMCPMC11887313

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