Evidence map›Paper›PMID 40050018›Full record

ArticleSexually transmitted infections2025

Investigation of ceftriaxone-resistant

Martin P McHugh, Kirsty Aburajab, Alexandra Maxwell, John Anderson, Fraser Cairns, Seb Cotton, Andrew Gough, Brian Malloy, Katharine Mathers, Lynne Renwick and 2 more

Abstract read
In one paragraph

Article in Sexually transmitted infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Martin P McHughNHS Lothian, Edinburgh, UK v1mmchug@ed.ac.uk.ORCID http://orcid.org/0000-0002-0370-3700
Kirsty AburajabNHS Forth Valley, Stirling, UK.
Alexandra MaxwellNHS Greater Glasgow and Clyde, Glasgow, UK.
John AndersonNHS Lothian, Edinburgh, UK.
Fraser CairnsNHS Lothian, Edinburgh, UK.
Seb CottonNHS Lothian, Edinburgh, UK.
Andrew GoughNHS Lothian, Edinburgh, UK.
Brian MalloyNHS Lothian, Edinburgh, UK.
Katharine MathersNHS Lothian, Edinburgh, UK.
Lynne RenwickNHS Lothian, Edinburgh, UK.
Jill ShepherdNHS Lothian, Edinburgh, UK.
Kate E TempletonNHS Lothian, Edinburgh, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDescribe the clinical, phenotypic and genomic characteristics of ceftriaxone-resistant

methodsCases were identified in routine care from 2018 to 2024. Minimum inhibitory concentrations were determined for seven antimicrobial agents. Whole genome sequencing was performed with Illumina and Oxford Nanopore Technology instruments. A phylogeny containing global ceftriaxone-resistant genomes was generated with Parsnp. A collection of ST8780 genomes was also analysed to give further context using reference-based mapping with Snippy.

resultsThere were five cases of ceftriaxone-resistant

conclusionsAs ceftriaxone resistance is increasingly identified, multiple public health interventions are required to reduce the impact of resistance on gonorrhoea treatment globally.

Indexed as

Anti-Bacterial AgentsCeftriaxoneDrug Resistance, BacterialGonorrheaNeisseria gonorrhoeaeAdultFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedMultilocus Sequence TypingPhylogenyScotlandWhole Genome SequencingYoung AdultAnti-Bacterial AgentsCeftriaxoneDrug Resistance, BacterialGonorrheaMOLECULAR EPIDEMIOLOGYNEISSERIA GONORRHOEAE

Identifiers

PMID40050018
PMCPMC12703345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.