Evidence map›Paper›PMID 40049745›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Biodistribution, Safety Profile, and Radiation Dosimetry of [

Juhani Knuuti, Małgorzata Kobylecka, Seweryn Krajewski, Lukasz Steczek, Karina Gotowicz, Joanna Towpik, Kari Kalliokoski, Tuula Tolvanen, Magdalena Kostkiewicz, Przemysław Kozanecki and 10 more

Abstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Juhani KnuutiTurku PET Centre and Faculty of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Małgorzata KobyleckaDepartment of Nuclear Medicine, Medical University of Warsaw, Warsaw, Poland.
Seweryn KrajewskiResearch and Development Centre, Synektik SA, Warsaw, Poland; skrajewski@synektik.com.pl.
Lukasz SteczekResearch and Development Centre, Synektik SA, Warsaw, Poland.
Karina GotowiczResearch and Development Centre, Synektik SA, Warsaw, Poland.
Joanna TowpikResearch and Development Centre, Synektik SA, Warsaw, Poland.
Kari KalliokoskiTurku PET Centre and Faculty of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Tuula TolvanenTurku PET Centre and Faculty of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Magdalena KostkiewiczDepartment of Cardiovascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
Przemysław KozaneckiResearch and Development Centre, Synektik SA, Warsaw, Poland.
Joanna WłostowskaResearch and Development Centre, Synektik SA, Warsaw, Poland.
Mirosław DziukNuclear Medicine Department, Military Institute of Medicine-National Research Institute, Warsaw, Poland.
Leszek KrólickiDepartment of Nuclear Medicine, Medical University of Warsaw, Warsaw, Poland.
Jacek BilNational Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland.
Piotr J SlomkaDepartments of Medicine and Cardiology, Cedars Sinai Medical Center, Los Angeles, California.
Timothy M BatemanMid America Heart Institute and the Saint Luke's Health System, Kansas City, Missouri.
Mouaz H Al-MallahHouston Methodist DeBakey Heart and Vascular Center, Houston, Texas.
Panithaya ChareonthaitaweeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota; and.
Prem SomanDivision of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Cezary KozaneckiResearch and Development Centre, Synektik SA, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A first-in-human phase I clinical study aimed to assess the safety profile, radiation dosimetry, and biodistribution of a potential cardiac PET myocardial perfusion imaging tracer, [

Indexed as

Fluorine RadioisotopesHeartMyocardial Perfusion ImagingPositron-Emission TomographyRadiopharmaceuticalsSafetyAdultFemaleHealthy VolunteersHumansMaleMiddle AgedRadiometryTissue DistributionFluorine-18Fluorine RadioisotopesRadiopharmaceuticals[18F]SYN2[18F]tracercardiac imagingMPIPET imagingphase I clinical study

Identifiers

PMID40049745
PMCPMC11960610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.