Evidence map›Paper›PMID 40049743›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Imaging Synaptic Density in Aging and Alzheimer Disease with [

Joseph Giorgio, David N Soleimani-Meigooni, Mustafa Janabi, Suzanne L Baker, Xi Chen, Tyler N Toueg, Robby Weimer, Bastian Zinnhardt, Ari Green, Gil D Rabinovici and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Assessment of noninvasive quantification of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph GiorgioDepartment of Neuroscience, University of California Berkeley, Berkeley, California; jgiorgio@berkeley.edu.
David N Soleimani-MeigooniMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California.
Mustafa JanabiLawrence Berkeley National Laboratory, Berkeley, California.
Suzanne L BakerLawrence Berkeley National Laboratory, Berkeley, California.
Xi ChenDepartment of Neuroscience, University of California Berkeley, Berkeley, California.
Tyler N TouegDepartment of Neuroscience, University of California Berkeley, Berkeley, California.
Robby WeimerGenentech, Inc; and.
Bastian ZinnhardtRoche Switzerland, Basel, Switzerland.
Ari GreenMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California.
Gil D RabinoviciMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California.
William J JagustDepartment of Neuroscience, University of California Berkeley, Berkeley, California.

Funding

Development of Emergent PET Tracers in Frontotemporal Lobar DegenerationK23AG076960 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David Nima Soleimani-Meigooni · 2022 to 2026
$951k
NIA NIH HHS K23 AG076960
6 · The paper itself

Abstract

Synaptic density imaging with PET is a relatively new approach to monitoring synaptic injury in neurodegenerative diseases. However, there are remaining technical and clinical questions, including questions on reference region selection and on how specific phenotypic presentations and symptoms of Alzheimer disease (AD) are reflected in alterations in synaptic density.

Indexed as

AgingAlzheimer DiseasePositron-Emission TomographySynapsesAdultAgedAged, 80 and overBrainFemaleFluorine RadioisotopesHumansMaleMembrane GlycoproteinsMiddle AgedPyridinesPyrrolidinesFluorine RadioisotopesMembrane GlycoproteinsPyridinesPyrrolidinesSynVesT-1Alzheimer diseasePET modelingsynaptic density

Identifiers

PMID40049743
PMCPMC11960604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.