Evidence map›Paper›PMID 40049542›Full record

ArticleMitochondrion2025

Drp1 knockdown aggravates obesity-induced cardiac dysfunction and remodeling.

Dan Wu, Qingxun Hu, Huimin Li, Yun Yin, Pei Wang, Wang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mitochondrion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dan WuMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA; Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Qingxun HuMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA; Shanghai Engineering Research Center of Organ Repair, Department of Pharmacy, School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address: qingxh@shu.edu.cn.
Huimin LiDepartment of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Yun YinDepartment of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Pei WangMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA.
Wang WangMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address: wangwang@uw.edu.

Funding

Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5M
Dynamin-Related Protein Drp1 Regulates Cardiac Excitation-Contraction-Bioenergetics CouplingR01HL137266 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI SHEU, SHEY-SHING, WANG, WANG · 2018 to 2021
$2.5M
Regulation and function of mitochondrial calcium uniporter in the heartR56HL153124 · NHLBI · UNIVERSITY OF WASHINGTON · PI WANG, WANG · 2022 to 2022
$736k
NEI NIH HHS P30 EY001730NHLBI NIH HHS R01 HL137266NHLBI NIH HHS R56 HL153124
6 · The paper itself

Abstract

Obesity is an independent risk factor for heart failure with preserved ejection fraction (HFpEF). Dynamin related protein 1 (Drp1) is a key regulator of mitochondrial morphology, bioenergetics and quality control. The role of endogenous Drp1 in obesity induced HFpEF remains largely unknown. Here, adult heterozygous Drp1 floxed (Drp1

Indexed as

DynaminsHeart FailureObesityAnimalsApoptosisDiet, High-FatMaleMiceMice, Inbred C57BLMice, KnockoutMitochondrial DynamicsMitophagyOxidative StressDnm1l protein, mouseDynaminsDynamin related protein 1Heart failure with preserved ejection fractionLipid overloadMitochondrial dysfunction

Identifiers

PMID40049542
PMCPMC12065651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.