ArticleNature2025
Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Harnessing fluorescent probes for molecular diagnosis and theranostics of atherosclerosis.Drug delivery · 2026Review
- Article
- Topology-Driven Mechanical Tuning of FDM-Printed TPU Tubular Lattices with Auxetic Architectures.Micromachines · 2026Article
- Review
- Fenofibrate attenuates hyperhomocysteinemia-potentiated thrombosis by restoring platelet fatty acid β-oxidation.Redox biology · 2026Article
- Screening for candidate genes and cell populations associated with atherosclerotic calcification using single-cell RNA sequencing.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Sphingolipids and Atherosclerosis.Current atherosclerosis reports · 2026Review
- E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression.EMBO reports · 2026Article
- Inflammation in atherosclerosis: Drivers, mechanisms and therapies.Acta pharmaceutica Sinica. B · 2026Review
- Single-cell transcriptomics uncovers endothelial progenitor-like remodelling driving human coronary atherosclerosis progression.Nature cell biology · 2026Article
- Ceramide-Driven Mechanisms in Pulmonary Fibrosis.Metabolites · 2026Review
- P2RY6Cellular oncology (Dordrecht, Netherlands) · 2026Article
- P2Y6 receptor in the superior cervical ganglion: a key mediator of post-myocardial ischemic sympathetic hyperexcitability via NF-κB mediated neuroinflammation.Purinergic signalling · 2026Article
- Circulating ceramides and sphingomyelins: key biomarkers and targets in cardiovascular prevention.Science China. Life sciences · 2026Review
- Metabolic reprogramming in aortic diseases: insights from metabolomics and therapeutic opportunities.Medical review (2021) · 2026Review
- Detergents without a drain: the evolutionary logic (and liability) of sphingolipids.Journal of lipid research · 2026Review
- Pyrimidinergic calcium signaling links tubular metabolism to fibrosis in kidney disease.Nature communications · 2026Article
- Regulatory roles of bioactive lipids in vascular homeostasis and remodeling.Medical review (2021) · 2026Review
- Exploring Ceramide C16:0 as a Novel Biomarker and Therapeutic Target for Atherosclerosis.Journal of the American Heart Association · 2026Review
- A Somatic Mutation in HIF-2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Siting Zhang *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.ORCID 0009-0000-2800-6525
Hui Lin *New Cornerstone Science Laboratory, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
Jiale Wang *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Jingyu Rui *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Tengwei Wang *New Cornerstone Science Laboratory, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
Zeyu Cai *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Shenming Huang *New Cornerstone Science Laboratory, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yanxiang GaoDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Tianfeng MaDepartment of Vascular and Endovascular Surgery, the First Medical Centre, Chinese PLA General Hospital, Beijing, China.
Rui FanDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.ORCID 0000-0001-6757-9422
Rongbo DaiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Zhiqing LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Yiting JiaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Qiang ChenDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
HaoMing HeDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.ORCID 0000-0001-7171-6098
Jiaai TanDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Shirong ZhuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Rui GuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Zhigang DongDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Meihong LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Enmin XieDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Yi FuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China.
Jingang ZhengDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China. mdjingangzheng@163.com.ORCID 0000-0002-3769-6166
Changtao JiangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China. jiangchangtao@bjmu.edu.cn.ORCID 0000-0002-5206-2372
Jinpeng SunState Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, P. R. China. sunjinpeng@sdu.edu.cn.ORCID 0000-0003-3572-1580
Wei KongDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, P. R. China. kongw@bjmu.edu.cn.ORCID 0000-0001-6720-6810
Funding
Cutting Edge Development Fund of Advanced Medical Research Institute (to J.S.), the New Cornerstone Science Foundation (to J.S.), the National High Level Hospital Clinical ResearchNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaState Key Program of National Natural Science Foundation of Chinathe National Science Fund for Distinguished Young Scholars
Abstract
Recent evidence has shown that increased levels of circulating long-chain ceramides predict atherosclerotic cardiovascular disease independently of cholesterol
Indexed as
AtherosclerosisCeramidesReceptors, LeukotrieneReceptors, Purinergic P2AnimalsCoronary Artery DiseaseFemaleHumansInflammasomesMacrophagesMaleMiceMice, Inbred C57BLModels, MolecularNLR Family, Pyrin Domain-Containing 3 ProteinRenal Insufficiency, ChronicCeramidescysteinyl leukotriene receptor 2InflammasomesNLR Family, Pyrin Domain-Containing 3 Proteinpurinoceptor P2Y6Receptors, LeukotrieneReceptors, Purinergic P2
Identifiers
PMID
40049228What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.