Evidence map›Paper›PMID 40049172›Full record

ArticleCurrent biology : CB2025

Formation of Drosophila germ cells requires spatial patterning of phospholipids.

Marcus D Kilwein, Pearson Miller, Kwan Yin Lee, Miriam Osterfield, Alex Mogilner, Stanislav Y Shvartsman, Elizabeth R Gavis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026
    Review
  3. Article
  4. Hedgehog and Drosophila germ cell migration.Development (Cambridge, England) · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Marcus D KilweinDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Pearson MillerCenter for Computational Biology, Flatiron Institute, New York, NY 10010, USA.
Kwan Yin LeeDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Miriam OsterfieldDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Alex MogilnerCourant Institute and Department of Biology, New York University, New York, NY 10012, USA.
Stanislav Y ShvartsmanDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA; The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. Electronic address: stas@princeton.edu.
Elizabeth R GavisDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: gavis@princeton.edu.

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Mechanisms of mRNA localization and translational control in Drosophila developmentR35GM126967 · NIGMS · PRINCETON UNIVERSITY · PI ELIZABETH R GAVIS · 2018 to 2026
$5.9M
Mechanism of RNA Localization in Drosophila DevelopmentR01GM067758 · NIGMS · PRINCETON UNIVERSITY · PI GAVIS, ELIZABETH R · 2004 to 2017
$5.3M
Collective dynamics in cell clustersR01GM134204 · NIGMS · PRINCETON UNIVERSITY · PI Stanislav Y. Shvartsman · 2019 to 2026
$2.6M
NIGMS NIH HHS R01 GM067758NIGMS NIH HHS R01 GM134204NIGMS NIH HHS R35 GM126967NIH HHS P40 OD018537
6 · The paper itself

Abstract

Germline-soma segregation is crucial for fertility. Primordial germ cells (PGCs) arise early in development and are the very first cells to form in the Drosophila embryo. At the time of PGC formation, the embryo is a syncytium where nuclei divide within a common cytoplasm. Whereas invaginating plasma membrane furrows enclose nuclei to form somatic lineages during the 14th nuclear division cycle, PGCs emerge from the syncytium during the 9th division cycle in a mechanistically distinct process. PGC formation depends on maternally deposited germ granules localized at the embryo's posterior pole. Germ granules trigger protrusion of membrane buds that enlarge to surround several nuclei that reach the posterior pole. Buds are remodeled to cells through mitotic division and constriction of the bud neck. Previous studies implicated F-actin,

Indexed as

Drosophila melanogasterGerm CellsPhospholipidsAnimalsEmbryo, NonmammalianPhospholipidsDrosophilagerm granulesgermlinePI4KαPIP2primordial germ cells

Identifiers

PMID40049172
PMCPMC12288159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.