Evidence map›Paper›PMID 40049169›Full record

ArticleAmerican journal of human genetics2025

Human leukocyte antigen variation is associated with cytomegalovirus serostatus in healthy individuals.

Juliano A Boquett, Jürgen Sauter, Alexander H Schmidt, Martin Maiers, Jill A Hollenbach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Juliano A BoquettDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Jürgen SauterDKMS Group, Tübingen, Germany.
Alexander H SchmidtDKMS Group, Tübingen, Germany.
Martin MaiersCIBMTR (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN, USA.
Jill A HollenbachDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: jill.hollenbach@ucsf.edu.

Funding

The landscape of HLA mediated variation in health and immunityR01AI158861 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON · 2021 to 2025
$3.5M
NIAID NIH HHS R01 AI158861
6 · The paper itself

Abstract

Cytomegalovirus (CMV) is a common β-herpes virus worldwide with an estimated seroprevalence among the general population of 83%. Primary infection is usually benign; however, CMV can cause severe morbidity in newborns in whom it is acquired congenitally, as well as immunocompromised individuals. Understanding the role of immunogenetic variation in risk for CMV infection can provide insight into the immune control of this ubiquitous pathogen. Here, we evaluated the association of human leukocyte antigen (HLA) genetic variation with CMV seropositivity in more than 518,000 individuals from two independent cohorts. We found three HLA class II alleles (HLA-DRB1

Indexed as

CytomegalovirusCytomegalovirus InfectionsGenetic VariationHLA AntigensHLA-DRB1 ChainsAllelesCohort StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMaleHLA AntigensHLA-DRB1 Chainsbinding pocketsCMVHLAimmunogeneticsinfectionserostatus

Identifiers

PMID40049169
PMCPMC12081270

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.