Evidence map›Paper›PMID 40048695›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Postoperative Outcomes in Normotensive and Hypertensive Pheochromocytomas: An International Study.

Marta Araujo-Castro, Aura Herrera, Yanbo Wang, Zhicheng Wang, Maciej Śledziński, Andrzej Hellmann, Marco Raffaelli, Francesco Pennestrì, Mark Sywak, Alexander J Papachristos and 69 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

79 authors.

Marta Araujo-CastroDepartment of Endocrinology, Hospital Universitario Ramón y Cajal, Madrid 28034, Spain.ORCID 0000-0002-0519-0072
Aura HerreraDepartment of Endocrinology and Nutrition, University Hospital Reina Sofia, Cordoba 14004, Spain.
Yanbo WangDepartment of Urology, The First Affiliated Hospital of Jilin University, Changchun, Jilin 2699, China.
Zhicheng WangDepartment of Urology, The First Affiliated Hospital of Jilin University, Changchun, Jilin 2699, China.
Maciej ŚledzińskiDivision of General, Endocrine and Transplant Surgery, Medical University of Gdańsk, Gdańsk 80210, Poland.
Andrzej HellmannDivision of General, Endocrine and Transplant Surgery, Medical University of Gdańsk, Gdańsk 80210, Poland.
Marco RaffaelliUOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Centro di Ricerca in Chirurgia Endocrina e dell'Obesità, Università Cattolica del Sacro Cuore, Rome 00136, Italy.ORCID 0000-0002-1259-2491
Francesco PennestrìUOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Centro di Ricerca in Chirurgia Endocrina e dell'Obesità, Università Cattolica del Sacro Cuore, Rome 00136, Italy.ORCID 0000-0003-0865-700X
Mark SywakEndocrine Surgical Unit, Royal North Shore Hospital, Northern Sydney Local Health District, Sydney, NSW 2065, Australia.
Alexander J PapachristosEndocrine Surgical Unit, Royal North Shore Hospital, Northern Sydney Local Health District, Sydney, NSW 2065, Australia.ORCID 0000-0003-4634-5963
Fausto F PalazzoDepartment of Endocrine Surgery, Hammersmith Hospital, London W12 OHS, UK.
Tae-Yon SungDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Byung-Chang KimDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Yu-Mi LeeDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Fiona EatockDepartment of Endocrine Surgery, Royal Victoria Hospital, Belfast BT12 6BA, UK.
Hannah AndersonDepartment of Endocrine Surgery, Royal Victoria Hospital, Belfast BT12 6BA, UK.
Maurizio IacoboneEndocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua 35143, Italy.ORCID 0000-0002-6057-4642
Albertas DaukšaDepartment of Surgery, Lithuanian University of Health Sciences, Kaunas 44307, Lithuania.
Ozer MakayOzel Saglik Hospital, Centre of Endocrine Surgery, Izmir 35000, Turkey.ORCID 0000-0002-6660-6748
Yigit TurkDivision of Endocrine Surgery, General Surgery Department, Ege University Hospital, Izmir 35100, Turkey.
Hafize Basut AtalayOzel Saglik Hospital, Centre of Endocrine Surgery, Izmir 35000, Turkey.
Els J M Nieveen van DijkumDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam 1081, the Netherlands.
Anton F EngelsmanDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam 1081, the Netherlands.ORCID 0000-0003-4943-8882
Isabelle HolscherDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam 1081, the Netherlands.ORCID 0000-0002-0585-1889
Gabriele MaterazziEndocrine Surgery Unit, University Hospital of Pisa, Pisa 56100, Italy.
Leonardo RossiEndocrine Surgery Unit, University Hospital of Pisa, Pisa 56100, Italy.
Chiara BecucciEndocrine Surgery Unit, University Hospital of Pisa, Pisa 56100, Italy.
Susannah L ShoreDepartment of Endocrine and Breast Surgery, Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool L7 8XP, UK.
Clare FungDepartment of Endocrine and Breast Surgery, Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool L7 8XP, UK.
Alison WaghornDepartment of Endocrine and Breast Surgery, Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool L7 8XP, UK.
Radu MihaiDepartment of Endocrine Surgery, Churchill Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.
Sabapathy P BalasubramanianDepartment of General Surgery, Sheffield Teaching Hospitals Foundation Trust, Sheffield S10 2JF, UK.
Arslan PannuDepartment of General Surgery, Sheffield Teaching Hospitals Foundation Trust, Sheffield S10 2JF, UK.
Shuichi TataranoDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
David Velázquez-FernándezServicio de Cirugía Endocrina y Laparoscopia Avanzada, Departamento de Cirugía, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
Julie A MillerEndocrine Surgery Unit, The Royal Melbourne Hospital, Melbourne, VIC 3050, Australia.
Hazel Serrao-BrownEndocrine Surgical Unit, Royal North Shore Hospital, Northern Sydney Local Health District, Sydney, NSW 2065, Australia.
Yufei ChenCedars-Sinai Medical Center, Department of Surgery, Los Angeles, CA 90048, USA.
Marco Stefano DemarchiDepartment of Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva, Geneva 1211, Switzerland.
Reza DjafarrianDepartment of Thoracic and Endocrine Surgery and Faculty of Medicine, University Hospitals of Geneva, Geneva 1211, Switzerland.
Helen DoranDepartment of Endocrine Surgery, Salford Royal Hospital, Salford M6 8HD, UK.
Kelvin WangDepartment of Endocrine Surgery, Salford Royal Hospital, Salford M6 8HD, UK.
Michael J StechmanDepartment of Endocrine Surgery, University Hospital Wales, Cardiff CF14 4XW, UK.
Helen PerryDepartment of Endocrine Surgery, University Hospital Wales, Cardiff CF14 4XW, UK.ORCID 0000-0003-3739-6048
Johnathan HubbardDepartment of Endocrine Surgery, St Thomas' Hospital, London SE1 7EH, UK.
Cristina LamasEndocrinology & Nutrition Department, Hospital Universitario de Albacete, Albacete 02008, Spain.ORCID 0000-0003-4622-9508
Philippa MercerEndocrine Surgical Unit, Department of General Surgery, Christchurch Hospital, Christchurch 4710, New Zealand.
Janet MacPhersonDepartment of Anaesthesia, Christchurch Hospital, Christchurch 4710, New Zealand.
Supanut LumbiganonDepartment of Surgery, Division of Urology, Khon Kaen University, Khon Kaen 40002, Thailand.
María CalatayudEndocrinology & Nutrition Department, Hospital Universitario 12 de Octubre, Madrid 28041, Spain.
Felicia Alexandra HanzuEndocrinology & Nutrition Department, Hospital Clinic University Barcelona, Barcelona 08036, Spain.
Oscar VidalEndocrine Surgery Department, Hospital Clinic University Barcelona, Barcelona 08036, Spain.
Cesar Minguez OjedaUrology Department, Hospital Universitario Ramón y Cajal, Madrid 28034, Spain.
Theodosios Papavramidis1st Propedeutic Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki 546 36, Greece.
Pablo Rodríguez de Vera GómezEndocrinology & Nutrition Department, Hospital Universitario Virgen de la Macarena, Sevilla 41009, Spain.
Abdulaziz AldreesEndocrine Surgery, Department of General Surgery, King Abdulaziz Medical City, Riyadh 14611, Saudi Arabia.
Tariq AltwjryEndocrine Surgery, Department of General Surgery, King Abdulaziz Medical City, Riyadh 14611, Saudi Arabia.
Nuria ValdésEndocrinology & Nutrition Department, Hospital Universitario Cruces  Barakaldo, Vizcaya 856350, Spain.
Cristina Álvarez-EscolaEndocrinology & Nutrition Department, Hospital Universitario La Paz, Madrid 28046, Spain.
Iñigo García SanzGeneral & Digestive Surgery Department, Hospital Universitario de La Princesa, Madrid 28006, Spain.
Concepción Blanco CarreraEndocrinology & Nutrition Department, Hospital Universitario Príncipe de Asturias, Madrid 28805, Spain.
Laura Manjón-MiguélezEndocrinology & Nutrition Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain.
Paz De Miguel NovoaEndocrinology & Nutrition Department, Hospital Clínico San Carlos, Madrid 28040, Spain.
Mónica RecasensEndocrinology & Nutrition Department, Institut Català de la Salut Girona, Girona 17005, Spain.
Rogelio García CentenoEndocrinology & Nutrition Department, Hospital Universitario Gregorio Marañón, Madrid 28007, Spain.
Cristina Robles LázaroEndocrinology & Nutrition Department, Hospital Universitario de Salamanca, Salamanca 37007, Spain.
Klaas Van Den HeedeGeneral and Endocrine Surgery, Onze-Lieve-Vrouw (OLV) Hospital Aalst-Asse-Ninove, Aalst, Belgium.ORCID 0000-0003-3642-9514
Sam Van SlyckeGeneral and Endocrine Surgery, Onze-Lieve-Vrouw (OLV) Hospital Aalst-Asse-Ninove, Aalst, Belgium.
Theodora MichalopoulouDepartment of Endocrinology and Nutrition, Joan XXIII University Hospital, Tarragona 43005, Spain.
Sebastian AspinallDepartment of General Surgery, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.
Ross MelvinDepartment of General Surgery, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.
Joel Wen Liang LauDivision of Breast & Endocrine Surgery, Department of General Surgery, Ng Teng Fong General Hospital (NTFGH), National University Health System (NUHS), Singapore 609606, Singapore.
Wei Keat CheahDivision of Breast & Endocrine Surgery, Department of General Surgery, Ng Teng Fong General Hospital (NTFGH), National University Health System (NUHS), Singapore 609606, Singapore.
Man Hon TangDivision of Breast & Endocrine Surgery, Department of General Surgery, Ng Teng Fong General Hospital (NTFGH), National University Health System (NUHS), Singapore 609606, Singapore.
Han Boon OhDivision of Breast & Endocrine Surgery, Department of General Surgery, Ng Teng Fong General Hospital (NTFGH), National University Health System (NUHS), Singapore 609606, Singapore.
John AyukDepartment of Endocrinology, Queen Elizabeth Hospital  B15 2GW, Birmingham, UK.
Kevin VerhoeffDepartment of Surgery, Division of General Surgery, University of Alberta, Faculty of Medicine & Dentistry, Edmonton, AB, Canada T6G 2R3.
Robert P SutcliffeDepartment of Hepatopancreatobiliary and Liver Transplant Surgery, Queen Elizabeth Hospital, Birmingham B15 2GW, UK.
Alessandro ParenteDepartment of Hepatopancreatobiliary and Liver Transplant Surgery, Queen Elizabeth Hospital, Birmingham B15 2GW, UK.ORCID 0000-0001-5506-224X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextPostoperative outcomes of patients with normotensive pheochromocytomas are poorly documented.

objectiveWe aimed to evaluate the impact of preoperative hypertension on postoperative outcomes following adrenalectomy for pheochromocytoma.

methodsAn international retrospective study of patients undergoing adrenalectomy for pheochromocytoma in 46 centers between 2012 and 2022 was performed. Hypertensive and normotensive pheochromocytoma were defined respectively by the presence or absence of hypertension history before or at the time of pheochromocytoma diagnosis. To evaluate differences in postoperative outcomes between hypertensive and normotensive patients, propensity score matched (PSM) analysis was performed.

resultsAmong 2016 patients with pheochromocytoma, 1034 (51.2%) had preoperative hypertension and 982 (49.8%) were normotensive. Hypertensive patients were 4.5 years older (P < .001), had a higher prevalence of type 2 diabetes (P < .001), had a higher median Charlson Comorbidity Index (2.0 vs 1.0; P < .001), and had an American Society of Anesthesiologists score of III to IV more frequently (41% vs 19.9%; P < .001) than normotensive patients. Nonadjusted analysis demonstrated that hypertensive patients had longer operative time (115.0 vs 103.5 minutes; P = .026), higher rate of vasopressors at skin closure (19.7% vs 15.4%; P = .013), more perioperative blood transfusions (7.7% vs 5.0%; P = .016), and an increased complication rate (21.6% vs 17.7%; P = .029). However, after 1:1 PSM, we found that readmission, complications, and serious complications were similar between cohorts.

conclusionPatients with hypertensive pheochromocytomas have a higher risk of postoperative complications than normotensive patients due to the association of hypertension with a higher burden of comorbidities and older age. However, hypertension is not an independent risk factor of postoperative complications after pheochromocytoma surgery.

Indexed as

AdrenalectomyAdrenal Gland NeoplasmsHypertensionPheochromocytomaPostoperative ComplicationsAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisPropensity ScoreRetrospective StudiesTreatment OutcomeClavin-Dindohypertensivenormotensivepheochromocytomasurgical outcomes

Identifiers

PMID40048695
PMCPMC12527436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.