Evidence map›Paper›PMID 40048662›Full record

ArticleEuropean heart journal2025

Common and divergent cellular aetiologies underlying hypoplastic left heart syndrome and hypoplastic right heart syndrome.

Yang Yu, Cankun Wang, Shiqiao Ye, Hannah Qin, Matthew Alonzo, Angela Onorato, Aaron Argall, Karen Texter, Qin Ma, Vidu Garg and 1 more

Abstract read
In one paragraph

Article in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yang YuCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Cankun WangDepartment of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Shiqiao YeCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Hannah QinCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Matthew AlonzoCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Angela OnoratoThe Heart Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Aaron ArgallCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Karen TexterThe Heart Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Qin MaDepartment of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.ORCID 0000-0002-3264-8392
Vidu GargCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Ming-Tao ZhaoCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.ORCID 0000-0002-9837-7548

Funding

An integrated human stem cell model for elucidating NOTCH signaling in myocardial-endocardial interactions in cardiac development and diseaseR01HL155282 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mingtao Zhao · 2021 to 2026
$3.2M
Statistical Power Analysis Framework for Multi-Sample and Cross-Platform Spatial Omics ExperimentsR01GM152585 · NIGMS · OHIO STATE UNIVERSITY · PI Dongjun Chung, Qin Ma · 2024 to 2026
$1.2M
Dissecting SARS-CoV-2 infection in Down syndrome with congenital heart defects using patient-specific iPSCsR21HL165406 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ZHAO, MINGTAO · 2022 to 2023
$429k
A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte ProliferationF32HL170581 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Matthew Alonzo · 2024 to 2026
$241k
Additional Ventures Innovation FundAHA/AV Collaborative Science Award 24AVCSASV1277994AHA Career Development Award 18CDA34110293AHA Innovative Project Award 23IPA1046350AHA Postdoctoral Fellowship 24POST1194909AHA Transformational Project Award 24TPA1288584NHLBI Diversity Supplement R01 HL155282-03S1NHLBI Diversity Supplement R01 HL155282-04S3NHLBI NIH HHS F32 HL170581NHLBI NIH HHS R01 HL155282NHLBI NIH HHS R21 HL165406NIGMS NIH HHS R01 GM152585NIGMS NIH HHS R01GM152585NIHNIH F32 Postdoctoral Fellowship HL170581-01A1Single Ventricle Research FundTools and Technology Expansion Award
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiac proliferationHypoplastic left heart syndromeHypoplastic right heart syndromeInduced pluripotent stem cells

Identifiers

PMID40048662
PMCPMC12093140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.