ArticleJournal of veterinary internal medicine
Renin-Angiotensin-Aldosterone System Profiling in Horses Before and After Exercise.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of furosemide on comprehensive renin-angiotensin-aldosterone system activity of Thoroughbred horses.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe impact of exercise on the classical and alternative renin-angiotensin-aldosterone system (RAAS) pathways has not been studied in horses. HYPOTHESIS: We hypothesized that exercise would activate both RAAS pathways and that endurance exercise would cause more activation of the classical pathway compared to short-duration, high-intensity exercise in horses. ANIMALS: Twenty-five horses (21 client-owned and 4 research) were included in 4 exercise groups (10 Arabians, 50-mile ride [A-E]; 4 thoroughbreds, 1-mile treadmill exercise [TB-TM]; 5 thoroughbreds, 1-1/16th-mile race [TB-R]; and 6 quarter horses 330-500-yard race [QH-R]).
methodsBlood was collected before and after exercise. Equilibrium analysis was performed to measure serum RAAS metabolites and enzyme activities. The components of the RAAS pathways were compared before and after exercise. Post/pre-exercise ratios for each variable were compared among exercise groups. Data were reported as median (first, third quartiles; pre vs. post) and p < 0.05 was considered significant.
resultsExercise increased classical RAAS metabolites (pmol/L; angiotensin I, 2.5 [2.5, 2.5] vs. 8.2 [2.5, 19.0]; angiotensin II, 10.2 [6.0, 21.9] vs. 53.0 [37.4, 95.8]; aldosterone, 83.8 [53.4, 149.5] vs. 170.6 [112.2, 251.7]); alternative RAAS metabolites (pmol/L; angiotensin 1-7, 1.5 [1.5, 1.5] vs. 5.1 [1.5, 12.5]; angiotensin 1-5, 2.5 [2.5, 7.3] vs. 14.9 [9.0, 25.4]) and angiotensin-converting enzyme-2 activity (ng/mL; 16.6 [13.9, 20.4] vs. 25.2 [20.2, 33.0]; p < 0.001) for all horses. Angiotensin 1-7 ratios were higher for TB-R compared with TB-TM and A-E (p < 0.001). CONCLUSIONS AND CLINICAL IMPORTANCE: Both classical and alternative RAAS pathways increase after exercise in horses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.