Evidence map›Paper›PMID 40048431›Full record

ArticleCell reports2025

Cell-type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development.

Ana Ortiz, Fatma Ayhan, Nitin Khandelwal, Elliot Outland, Miranda Jankovic, Matthew Harper, Genevieve Konopka

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Concordant transcriptional and morphological remodeling revealed bybioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ana OrtizDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Fatma AyhanDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Nitin KhandelwalDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Elliot OutlandDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Miranda JankovicDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Matthew HarperDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Genevieve KonopkaDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: genevieve.konopka@utsouthwestern.edu.

Funding

Foxp-regulated signaling pathways in brain development - DiversityR01MH126481 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI KONOPKA, GENEVIEVE · 2021 to 2025
$3.4M
The role of Foxp1-regulated signaling pathways in brain development and behaviorR01MH102603 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI KONOPKA, GENEVIEVE · 2015 to 2019
$2.2M
Mechanisms of Disease & Translational ScienceT32GM109776 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI YIN, HELEN L · 2014 to 2018
$573k
The Foxp2 Influence on the Developing Auditory PathwayF30DC022213 · NIDCD · UT SOUTHWESTERN MEDICAL CENTER · PI Miranda Jankovic · 2024 to 2026
$128k
Determining the cell type specific roles of Foxp1 in cortical development.F31MH123140 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI ORTIZ, ANA KAREN · 2020 to 2020
$13k
NIDCD NIH HHS F30 DC022213NIGMS NIH HHS T32 GM109776NIMH NIH HHS F31 MH123140NIMH NIH HHS R01 MH102603NIMH NIH HHS R01 MH126481
6 · The paper itself

Abstract

Forkhead box protein P1 (FOXP1), a transcription factor enriched in the neocortex, is associated with autism spectrum disorders (ASDs) and FOXP1 syndrome. Emx1

Indexed as

Cell LineageForkhead Transcription FactorsNeocortexNeuronsRepressor ProteinsAnimalsAutism Spectrum DisorderCell MovementGene Expression Regulation, DevelopmentalMiceMice, KnockoutNeurogenesisForkhead Transcription FactorsFoxp1 protein, mouseRepressor Proteinsautism spectrum disorderCortical developmentcorticogenesisCP: Developmental biologyCP: NeuroscienceFOXP1multiomicsneurodevelopmental disorderssingle cell genomics

Identifiers

PMID40048431
PMCPMC12051487

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.