ArticleJournal of veterinary internal medicine
Prognostic Roles of Trace Element and Cobalamin Concentrations in Dogs With Parvoviral Enteritis.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Reference Intervals for Trace Elements in Canine Plasma.Animals : an open access journal from MDPI · 2026Article
- Dioscin in liver diseases: pharmacological mechanisms, translational potential and future perspectives.Frontiers in pharmacology · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe trace elements copper (Cu), zinc (Zn), and selenium (Se) have been the focus of research into their potential roles in the prognosis of gastrointestinal disorders in humans.
objectiveEvaluation of the predictive potential serum concentrations of Cu, Zn, Cu/Zn, Se, and cobalamin as possible prognostic indicators in dogs with parvoviral enteritis (CPV). ANIMALS: Client-owned dogs diagnosed with CPV (n = 20) and healthy controls (n = 10).
methodsA case-controlled study. Serum concentrations of Cu and Zn were measured using a spectrophotometric method; serum Se levels were determined by mass spectrophotometry; and serum cobalamin concentrations were assessed using a chemiluminescent immunoassay method. The Mann-Whitney U test was employed to compare subgroup medians.
resultsUpon admission, surviving dogs with CPV (n = 10) exhibited higher serum Cu concentrations (median = 154.24; range = 60.15-188.46 μg/dL) and Cu/Zn ratios (median = 1.52; range = 0.67-2.45), alongside lower serum Zn concentrations (median = 88.05; range = 51.3-129.2 μg/dL) and cobalamin levels (median = 252.5; range = 111-396 pg/mL), compared to the control group (Cu, median = 72.12; range = 47.04-90.26 μg/dL), Zn (median = 184.2; range = 73.0-262.7 μg/dL), Cu/Zn (median = 0.37; range = 0.26-0.73), cobalamin (median = 638.5; range = 306.0-1016 pg/mL). Additionally, non-surviving dogs (n = 10) exhibited markedly higher serum Cu concentrations (median = 193.5; range = 125.0-229.0 μg/dL) and Cu/Zn ratios (median = 5.45; range = 1.95-9.23), and significantly lower serum Zn (median = 37.75; range = 24.8-71.6 μg/dL), Se (median = 52.45; range = 21.27-91 μg/L), and cobalamin levels (median = 52.2; range = 20.0-147.0 pg/mL) compared to both survivors and controls. CONCLUSIONS AND CLINICAL IMPORTANCE: Statistical variations in serum concentrations of Cu, Zn, and cobalamin, alongside Cu/Zn ratios, were observed among survivors, non-survivors, and controls (control-survivor and survivor-non-survivor: p < 0.05 and control-non-survivor: p < 0.01), which might suggest their potential prognostic value in CPV.
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