Evidence map›Paper›PMID 40048322›Full record

ArticleJournal of applied clinical medical physics2025

Multi-institutional study on image quality for a novel CBCT solution on O-ring linac.

Luis Agulles-Pedrós, R Lee MacDonald, Amanda Jean Cherpak, Nayha Dixit, Lei Dong, Tianyu Zhao, Kundan Thind, Anthony Doemer, Boon-Keng Teo, Shiqin Su and 2 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Luis Agulles-PedrósDepartment of Medical Physics, Nova Scotia Health, Halifax, Nova Scotia, Canada.ORCID https://orcid.org/0000-0003-1210-0511
R Lee MacDonaldDepartment of Medical Physics, Nova Scotia Health, Halifax, Nova Scotia, Canada.
Amanda Jean CherpakDepartment of Medical Physics, Nova Scotia Health, Halifax, Nova Scotia, Canada.
Nayha DixitPhysics Clinical Operations, Varian Advanced Oncology Solutions, Palo Alto, California, USA.
Lei DongDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-2623-3198
Tianyu ZhaoRadiation Oncology, University of South Florida, Tampa, Florida, USA.
Kundan ThindRadiation Oncology, Henry Ford Health, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-8261-6655
Anthony DoemerRadiation Oncology, Henry Ford Health, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0003-4087-598X
Boon-Keng TeoDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Shiqin SuRadiation Physics, Unviersity of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0009-0000-2061-2758
Alexander MoncionDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
James L RobarDepartment of Medical Physics, Nova Scotia Health, Halifax, Nova Scotia, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis work presents a multi-institutional study on image quality provided by a novel cone beam computed tomography (CBCT). The main goal is to investigate the consistency of imaging performance across multiple institutions.

methodsPhantoms for measuring relative electron density (RED) and image quality were sent to six institutions for imaging on Ethos and Halcyon units equipped with HyperSight CBCT. The imaging protocols included tube potential from 100 to 140 kVp and exposure from 80 to 800 mAs. Imaging performance was evaluated with regard to RED versus Hounsfield units (HU), uniformity, contrast-to-noise ratio (CNR), slice thickness, circular symmetry, modulation transfer function (MTF), and spatial resolution.

resultsAmong all institutions, some variability was observed among institutions in the RED-to-HU relationship, especially for RED values greater than 1, although no outliers were found (|z-score| < 2 in all cases). In this range, RED/HU slopes were 475 ± 25 10

conclusionsThis multi-institutional analysis of CBCT imaging performance showed consistency in radial uniformity, circular symmetry, integral nonuniformity, contrast, and spatial resolution. Some variability was seen in the RED-to-HU relationship for RED > 1 depending on exposure. More data from different institutions would be necessary to establish more robust statistical metrics, which ensure quality parameters.

Indexed as

Cone-Beam Computed TomographyImage Processing, Computer-AssistedParticle AcceleratorsPhantoms, ImagingRadiotherapy Planning, Computer-AssistedHumansRadiotherapy DosageRadiotherapy, Intensity-ModulatedSignal-To-Noise RatioCBCTimage analysisimage qualitynew technologyphantom image

Identifiers

PMID40048322
PMCPMC12148799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.