Evidence map›Paper›PMID 40048299›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2025

Hemostatic Outcome Definitions in Pediatric Extracorporeal Membrane Oxygenation: Challenges in Cohorts From Rotterdam (2019-2023) and Melbourne (2016-2022).

Joppe Drop, Suelyn Van Den Helm, Natasha Letunica, Enno Wildschut, Matthijs de Hoog, Willem de Boode, Rebecca Barton, Hui Ping Yaw, Fiona Newall, Stephen Horton and 11 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. "In-Series" Continuous Renal Replacement Therapy and Therapeutic Plasma Exchange: Single-Center Retrospective Cohort, 2018-2022.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Joppe DropDepartment of Pediatrics, Division of Pediatric Hematology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.ORCID 0000-0001-6898-1595
Suelyn Van Den HelmHaematology Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Natasha LetunicaHaematology Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Enno WildschutDepartment of Paediatrics, Division of Pediatric Intensive Care and Pediatric Surgery, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.
Matthijs de HoogDepartment of Paediatrics, Division of Pediatric Intensive Care and Pediatric Surgery, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.
Willem de BoodeDepartment of Neonatology, Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children's Hospital, Nijmegen, The Netherlands.
Rebecca BartonHaematology Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Hui Ping YawHaematology Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Fiona NewallHaematology Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Stephen HortonDepartment of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia.
Roberto ChilettiDepartment of Intensive Care, The Royal Children's Hospital, Melbourne, VIC, Australia.
Amy JohansenDepartment of Intensive Care, The Royal Children's Hospital, Melbourne, VIC, Australia.
Derek BestDepartment of Intensive Care, The Royal Children's Hospital, Melbourne, VIC, Australia.
Joanne McKittrickDepartment of Intensive Care, The Royal Children's Hospital, Melbourne, VIC, Australia.
Warwick ButtDepartment of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia.
Yves d'UdekemDepartment of Cardiac Surgery, Children's National Heart Institute, Washington, DC.
Graeme MacLarenCardiothoracic Intensive Care Unit, National University Health System, Singapore.
Vera IgnjatovicHaematology Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Chantal AttardHaematology Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
C Heleen van OmmenDepartment of Pediatrics, Division of Pediatric Hematology, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.
Paul MonagleHaematology Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.

Funding

KNAW Ter Meulen Grant, Sophia Kinderziekenhuis Fonds, Australian National Health and Medical Research Council 1129317.
6 · The paper itself

Abstract

objectivesTo determine if a priori standardization of outcome hemostatic definitions alone was adequate to enable useful comparison between two cohorts of pediatric extracorporeal membrane oxygenation (ECMO) patients, managed according to local practice and protocol.

designComparison of two separate prospective cohort studies performed at different centers with standardized outcome definitions agreed upon a priori.

settingGeneral and cardiac PICUs at the Royal Children's Hospital (RCH) in Melbourne, Australia, and the Sophia Children's Hospital (SCH) in Rotterdam, The Netherlands. PATIENTS: Children (0-18 yr old) undergoing ECMO.

interventionsNone. MEASUREMENTS AND MAIN

resultsAlthough outcome definitions were standardized a priori, the interpretation of surgical interventions varied. The SCH study included 47 ECMO runs (September 2019 to April 2023), and the RCH study included 97 ECMO runs (September 2016 to Jan 2022). Significant differences in patient populations were noted. RCH patients biased toward frequent cardiac ECMO indications, central cannulation, and cardiopulmonary bypass before ECMO. The frequency of outcome ascertainment was not standardized.

conclusionsThis international comparison shows that standardizing hemostatic outcome definitions alone is insufficient for sensible comparison. Uniform interpretation of definitions, consistent frequency of outcome ascertainment, and stratification based on patient populations and ECMO practices are required. Our results highlight the granularity of detail needed for cross-center comparison of hemostatic outcomes in pediatric ECMO. Further work is needed as we move toward potential multicenter trials of pediatric ECMO.

Indexed as

Extracorporeal Membrane OxygenationHemostasisAdolescentAustraliaChildChild, PreschoolFemaleHospitals, PediatricHumansInfantInfant, NewbornIntensive Care Units, PediatricMaleNetherlandsProspective StudiesTreatment Outcome

Identifiers

PMID40048299
PMCPMC11878593

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.