Evidence map›Paper›PMID 40048187›Full record

ArticleInvestigative ophthalmology & visual science2025

The Epidemiology of Eye Cancer, Eyelid Cancer, and Ophthalmic Lymphoma in a Chinese Population in Hong Kong: A Population-Based Registry Study 2005-2018.

Allie Lee, Dennis T W Law, Alex H S Kan, Flores F P Cruz, Vishal Jhanji, Hunter K L Yuen, Michael Y Ni

Abstract read
In one paragraph

Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Allie LeeDepartment of Ophthalmology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Dennis T W LawLi Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Alex H S KanDepartment of Ophthalmology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Flores F P CruzSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Vishal JhanjiDepartment of Ophthalmology, The University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Hunter K L YuenHong Kong Eye Hospital, Hong Kong SAR, People's Republic of China.
Michael Y NiSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the incidence rate, histopathological types, and time trends of primary eye cancer, eyelid cancer, and ophthalmic lymphoma among the Chinese population. Methods: The records of patients diagnosed with primary eye and eyelid cancers from 2005 to 2018 in Hong Kong were retrieved from the Hong Kong Cancer Registry. Patient demographics, cancer sites, and histology were recorded. Population-level age-standardized incidences and trends were analyzed by age and sex and compared with existing literature. International Classification of Diseases, Ninth Edition (ICD-9) codes were converted to ICD-10 codes. Eye cancer was defined as malignancy involving the eyeball, intraocular structures, lacrimal system, and orbit. Results: A total of 442 eye cancers and 1103 eyelid cancers were included. Among these cancers, 295 cases were ophthalmic lymphoma. The age-standardized annual incidence rate was 4.04 per 1,000,000 population for eye cancer, 6.30 for eyelid cancer, and 1.89 for ophthalmic lymphoma. The incidence rates increased with age (P < 0.001), but there were no sex differences. The incidence rate of eyelid cancer and ophthalmic lymphoma showed an increasing trend, with annual percent changes of 2.8% and 2%, respectively. In eye cancers, the most common histological type was lymphoma (58.1%), and the most common site was orbit (35.5%). The most common histology for eyelid cancer was basal cell carcinoma, and for ophthalmic lymphoma it was extranodal marginal zone B cell lymphoma. Conclusions: In the Chinese population, the incidence of eye cancer has remained stable, whereas eyelid cancer and ophthalmic lymphoma are increasing. Lymphoma has been the most common histological type in recent years, in contrast to findings in Western populations.

Indexed as

Eyelid NeoplasmsEye NeoplasmsLymphomaRegistriesAdolescentAdultAgedAged, 80 and overAge DistributionChildChild, PreschoolEast Asian PeopleFemaleHong KongHumansIncidence

Identifiers

PMID40048187
PMCPMC11895851

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.