Evidence map›Paper›PMID 40048117›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Increased risk of ischemic stroke in amyotrophic lateral sclerosis: a nationwide cohort study in South Korea.

Soonwook Kwon, Bongseong Kim, Kyung-Do Han, Wonyoung Jung, Eun Bin Cho, Dong Wook Shin, Ju-Hong Min

Abstract read
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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Soonwook KwonDepartment of Neurology, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea.ORCID http://orcid.org/0000-0002-5578-7571
Bongseong KimDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-1022-3553
Kyung-Do HanDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-6096-1263
Wonyoung JungDepartment of Family Medicine, Kangdong Sacred Heart Hospital, Hallym University, Seoul, South Korea.ORCID http://orcid.org/0000-0003-4749-4637
Eun Bin ChoDepartment of Neurology, Gyeongsang Institute of Health Science, Gyeongsang National University of Medicine, Jinju, South Korea.ORCID http://orcid.org/0000-0003-2021-8587
Dong Wook Shin *Department of Clinical Research Design and Evaluation, Department of Digital Health, Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, South Korea. dwshin.md@gmail.com.ORCID http://orcid.org/0000-0001-8128-8920
Ju-Hong Min *Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. juhongm@skku.edu.ORCID http://orcid.org/0000-0002-7338-9067

Funding

Ministry of Health and Welfare HI20C1073
6 · The paper itself

Abstract

backgroundWe investigated the risk of ischemic stroke in ALS and analyzed the effect of ALS-related physical disability using the Korean National Health Insurance Service database.

methodsA total of 2,251 ALS patients diagnosed between January 1, 2012, and December 31, 2015, and 1:10 age- and sex-matched control populations were included. Cases that participated in the national health check-up programs were selected. A Cox hazard regression model was used to examine the hazard ratios (HRs) for ischemic stroke in ALS after adjusting for potential confounders.

resultsA total of 681 ALS patients and 10,934 non-ALS participants were selected. ALS patients were slightly younger than the control group (60.3 ± 10.1 years vs. 61.0 ± 10.5 years, p = 0.105), and the proportion of male patients was similar between the two groups (61.6% vs. 60.9%, p = 0.722). ALS patients were more likely to have a lower body mass index (23.1 ± 2.92 vs. 24.0 ± 3.1, p < 0.001) and obstructive sleep apnea syndrome (0.59% vs. 0.06%, p < 0.001) than the controls. In ALS patients, the incidence rate of ischemic stroke was 6.32 per 1,000 person-years, and the adjusted HR of ischemic stroke was 2.58 (95% confidence interval 1.38 - 4.82) compared with the matched group. The risk of ischemic stroke did not differ by the presence of disability in ALS patients.

conclusionsOur findings suggest that ALS patients have an increased risk of ischemic stroke compared with controls, but the risk did not differ by the presence of disability in ALS.

Indexed as

Amyotrophic Lateral SclerosisIschemic StrokeAgedCohort StudiesFemaleHumansMaleMiddle AgedRepublic of KoreaRisk FactorsAmyotrophic lateral sclerosisEpidemiologyIschemic strokePhysical disabilitySouth Korea

Identifiers

PMID40048117

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.