Evidence map›Paper›PMID 40048115›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Real-world application of Short Term Psychodynamic Psychotherapy (STPP) as chronic migraine preventive therapy: Profiling responders and predictive factors.

Alessandro Viganò, Barbara Petolicchio, Massimiliano Toscano, Sonia Ruggero, Romina Di Giambattista, Marta Puma, Jacopo Lanzone, Angelo Bellinvia, Nicholas Diani, Matteo Castaldo and 6 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alessandro Viganò *IRCCS- Fondazione Don Carlo Gnocchi, Milan, Italy. avigano@dongnocchi.it.ORCID http://orcid.org/0000-0002-8079-5354
Barbara Petolicchio *Department of Human Neurosciences, Sapienza- University of Rome, Rome, Italy.
Massimiliano ToscanoDepartment of Human Neurosciences, Sapienza- University of Rome, Rome, Italy.
Sonia RuggeroDepartment of Neurology, AOU L. Vanvitelli, Naples, Italy.
Romina Di GiambattistaIstituto Europeo di Psicoterapia Psicanalitica, IREP, Rome, Italy.
Marta PumaDepartment of Human Neurosciences, Sapienza- University of Rome, Rome, Italy.
Jacopo LanzoneClinical Neurophysiology Service, Neurology Unit, IRCCS, San Raffaele Hospital, Milan, Italy.
Angelo BellinviaIRCCS- Fondazione Don Carlo Gnocchi, Milan, Italy.
Nicholas DianiIRCCS- Fondazione Don Carlo Gnocchi, Milan, Italy.
Matteo CastaldoDepartment of Health Science and Technology, Centre for Pain and Neuroplasticity (CNAP), SMI, School of Medicine, Aalborg University, Aalborg, Denmark.
Chiara ValotaIRCCS- Fondazione Don Carlo Gnocchi, Milan, Italy.
Rita De SanctisDepartment of Medical Oncology and Hematology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Paola TiberioDepartment of Medical Oncology and Hematology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Marta AltieriDepartment of Human Neurosciences, Sapienza- University of Rome, Rome, Italy.
Edmond GilliéronIstituto Europeo di Psicoterapia Psicanalitica, IREP, Rome, Italy.
Vittorio Di PieroDepartment of Human Neurosciences, Sapienza- University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAmong non-pharmacological approach for chronic migraine (CM), Short-Term Psychodynamic Psychotherapy (STPP) is suggested in CM and, particularly, in interrupting medication overuse (MO). In this study, we aim at identifying clinical predictive factors to identify CM patients who could more likely respond to STPP.

methodsWe designed a prospective real-world observational study on CM patients undergoing STPP. We collected clinical data related to migraine burden (baseline headache days, number of acute medications used, MIDAS, HIT-6), as well as psychiatric comorbidities (though MINI) and mentalization level obtained by the STPP first interview phase (called BPI) to use them as predictive factors by univariate and discriminant function analysis at 3 (early) and 6 months (only sustained response).

resultsWe recruited 119 patients (mean age 39.90 ± 14.4, F = 102); 113(94%) completed the STPP treatment. All patients presented a low-to-intermediate mentalization level. After stand-alone STPP, we observed a reduction in monthly headache days and MO at 3 months. Mentalization level didn't affect the STPP outcome (p = 0.40). Early response was directly related to a higher baseline headache days number, the previous used of alternative therapies, and higher Hamilton Depression scale scores. Sustained response was predicted by current use of preventive therapy, pain intensity, HIT-6 score, hypomania, and dysthymia.

conclusionThis real-world study showed that STPP could represent a valid therapeutic option in complex CM patients with a high number of headache days and comorbid depression.

Indexed as

Migraine DisordersPsychotherapy, PsychodynamicAdultChronic DiseaseFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeChronic migraineMentalizationPredictive modelPreventive therapyPsychotherapy

Identifiers

PMID40048115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.