Evidence map›Paper›PMID 40048021›Full record

ArticleMolecular imaging and biology2025

Dual Targeting of Neuropilin-1 and Glucose Transporter for Efficient Fluorescence Imaging of Cancer.

Jianwei Zhu, Can Zhou, Jian Yang, Zhenhua Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jianwei ZhuDepartment of Gastroenterology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, 201800, China.
Can ZhouSchool of Medicine, Shanghai University, Shanghai, 200444, China.
Jian YangSchool of Medicine, Shanghai University, Shanghai, 200444, China. yj_scu@163.com.
Zhenhua WangDepartment of Gastroenterology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, 201800, China. zhenhuaw@sjtu.edu.cn.

Funding

Shanghai Jiading District Health Committee Fund 2023-KY-21
6 · The paper itself

Abstract

purposeEarly diagnosis and complete resection of cancer are pivotal for enhancing patient survival rates and prognosis. However, a significant current challenge lies in the lack of specific imaging probes for the identifying various tumor types. The expression levels of neuropilin-1 (NRP1) and glucose transporter 1 (GLUT1) in most tumors, including breast cancer, are closely linked to tumor proliferation and metastasis. This study seeks to develop a novel near-infrared fluorescence (NIRF) probe aimed at precise tumor detection by targeting NRP1 and GLUT1. PROCEDURES: G

resultsA dual-targeting fluorescent probe named NGF was successfully synthesized to bind to both NRP1 and GLUT1 receptors. NGF exhibited greater hydrophilicity (Log P = -0.95 ± 0.07) and superior optical properties compared to its precursor, G

conclusionsThis study highlighted the efficient targeting and sustained retention of the dual-target heterodimeric fluorescent probe NGF, binding to NRP1 and GLUT1 receptors. These findings suggest significant potential for clinical applications in early cancer detection and fluorescence image-guided surgery.

Indexed as

Glucose Transporter Type 1NeoplasmsNeuropilin-1Optical ImagingAnimalsCell Line, TumorFemaleFluorescent DyesHumansFluorescent DyesGlucose Transporter Type 1Neuropilin-1CancerDual-targetingFluorescence imagingGlucose transporter 1 (GLUT1)Neuropilin-1 (NRP1)

Identifiers

PMID40048021
PMCPMC12062102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.