Evaluation of antioxidant, anti-inflammatory, and analgesic potentials of combined polyphenol-rich fractions from Ziziphus mauritiana and Ziziphus spina-christi leaves through modulation of inflammatory and oxidative stress markers in Sprague Dawley rats model.

Abstract read

In one paragraph

Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Polyphenol-rich Cucurbita formulation mitigates doxorubicin-induced cardiotoxicity in rats: biochemical, histological, and molecular docking insights.Scientific reports · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bader AlsuwaytDepartment of Pharmacy Practice, College of Pharmacy, University of Hafr Al Batin, 39524, Hafr Al Batin, Saudi Arabia. balsuwayt@uhb.edu.sa.ORCID http://orcid.org/0000-0002-3435-7994

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main objective of the present study was to combine the ethanol extracts of Ziziphus mauritiana and Ziziphus spina-christi (ZMZS) and fractioned with different solvents of increasing polarity for evaluation of antioxidant, anti-inflammatory and analgesic potentials. The ethanolic extracts of leaves were prepared using Soxhlet apparatus, mixed in ratio (1:1 w/w) and then fractionated into n-hexane, ethyl acetate and n-butanol. In vitro antioxidant activity of all fractions was assessed using total phenolic contents (TPC), total flavonoid contents (TFC), 2,2-dipehnyl, 1-picryl hydrazyl (DPPH) free radical scavenging ability, reducing power and bleachability of β-carotene in Linoleic acid system assays. Ethyl acetate fraction (EAF) showed the highest antioxidant activity in terms of the highest TPC (212.15 mg/g) and TFC (39.54 mg/g), better DPPH radical scavenging (IC

Indexed as

AnalgesicsAnti-Inflammatory AgentsAntioxidantsOxidative StressPlant ExtractsPolyphenolsZiziphusAnimalsBiomarkersDisease Models, AnimalEdemaInflammationMalePlant LeavesRatsRats, Sprague-DawleyAnalgesicsAnti-Inflammatory AgentsAntioxidantsBiomarkersPlant ExtractsPolyphenolsAnalgesicAnti-inflammatoryBioactive compoundsCoumarinIL-6SynergyTNF-αZiziphus mauritianaZiziphus spina-christi

Identifiers

PMID40048014

DOI10.1038/s41392-021-00658-5

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.