ArticleBrain imaging and behavior2025
Reduced local functional connectivity correlates with atypical performances in children with autism spectrum disorder.
Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Autism Spectrum Disorder-Associated Genes Enrich in Discrete Cortical, Limbic and Cerebellar Brain Regions.The European journal of neuroscience · 2026Article
- Venous Nanoflap Oscillations: Biomechanical Determinants and Hydrodynamic Consequences in the Deep Cerebral Venous System.International journal of molecular sciences · 2026Review
- Comparative effectiveness of virtual reality vs. traditional motor games on developmental functioning and motor skills in autistic children spectrum disorder: a cohort study.Frontiers in pediatrics · 2026Article
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Authors and funding
21 authors.
Funding
Abstract
To characterize local functional connectivity (FC) differences in children with autism spectrum disorder (ASD) compared to typically developed (TD) children, and to analyze the correlation between local FC and the atypical behavior in autistic children. Thirty children with ASD and 25 TD children were recruited. Participants underwent rs-fMRI scans, and regional homogeneity (ReHo) of specific brain regions was measured. Performance was assessed using the Autism Behavior Checklist (ABC) and the Gesell Development Diagnosis Scale (GDDS). Children with ASD demonstrated reduced ReHo in the right occipital lobe lingual, left postcentral, and left precuneus compared with TD children. Within the ASD group, the ABC total score was negatively related to ReHo values in both the left postcentral and left precuneus. The ReHo value in the left postcentral was negatively correlated with ABC scores related to sensory and body/object use, while the ReHo value in the left precuneus was negatively correlated with scores related to social skills and self-help. The mean Developmental Quotient (DQ) of GDDS was positively correlated with the ReHo value in the right occipital lobe lingual. Besides, the ReHo value in this region was positively correlated with the DQ of adaptive behavior. The ReHo value in the left postcentral was positively correlated with the DQ of fine motor skills (p < 0.05 for all). Children with ASD exhibit reduced local FC in specific brain regions, which are associated with specific performances in autism. These findings may provide a novel insight into the pathophysiological mechanisms of ASD.
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