SynthesisClinical rheumatology2025
The association between dyslipidemia and hand osteoarthritis: a systematic review and meta-analysis.
Synthesis in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review).International journal of molecular medicine · 2026Review
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- Revisiting the Subtle Relationship Between Metabolic Syndrome and Osteoarthritis.Journal of inflammation research · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundHand osteoarthritis (HOA) is a prevalent degenerative joint disease, with emerging evidence suggesting metabolic factors, including dyslipidemia, play a role in its pathogenesis. Dyslipidemia components, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, may contribute to cartilage damage and inflammation in hand joints, though robust evidence is limited.
methodA systematic review and meta-analysis were conducted using PubMed, Embase, and Web of Science to identify case-control and cohort studies examining the association between dyslipidemia and HOA. Dyslipidemia was assessed as a binary variable, while LDL, HDL, and triglycerides were analyzed as continuous variables. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. Random effects model was used to calculate standardized mean differences (SMDs) and odds ratios (ORs). This study adhered to PRISMA guidelines for transparent reporting and was registered with the International Prospective Register of Systematic Reviews (CRD42024616873).
resultsFor dyslipidemia (binary), the pooled OR was 1.40 (95% CI = 1.19-1.66, P < 0.0001) with negligible heterogeneity (I
conclusionThis meta-analysis reveals a moderate association between dyslipidemia, especially elevated triglycerides, and HOA. While lipid abnormalities may play a role in HOA development, the evidence for LDL and HDL is less clear. Limitations in study definitions and populations suggest the need for further research to better understand these relationships and their implications for prevention and management strategies in HOA.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.