Evidence map›Paper›PMID 40047966›Full record

ArticleEuropean journal of nutrition2025

Association of whole blood multi-micronutrients with mild cognitive impairment in Chinese older adults: a matched case-control study.

Zehao Wang, Cheng Cheng, Huilian Duan, Xukun Chen, Wen Li, Fei Ma, Zhenshu Li, Jing Yan, Ruikun He, Zhongxia Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zehao Wang *Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.
Cheng Cheng *Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.
Huilian DuanDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.
Xukun ChenDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.
Wen LiDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.
Fei MaTianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 300070, China.
Zhenshu LiDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China.
Jing YanTianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 300070, China.
Ruikun HeBYHEALTH Institute of Nutrition & Health, No. 916 Huangpu Avenue East, Yuzhu Sub-district, Huangpu District, Guangzhou, 510700, China.
Zhongxia LiBYHEALTH Institute of Nutrition & Health, No. 916 Huangpu Avenue East, Yuzhu Sub-district, Huangpu District, Guangzhou, 510700, China.
Mengtong YangBYHEALTH Institute of Nutrition & Health, No. 916 Huangpu Avenue East, Yuzhu Sub-district, Huangpu District, Guangzhou, 510700, China.
Zhenghua HuangBYHEALTH Institute of Nutrition & Health, No. 916 Huangpu Avenue East, Yuzhu Sub-district, Huangpu District, Guangzhou, 510700, China.
Yongjie ChenTianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, 300070, China. chenyongjie@tmu.edu.cn.
Guowei HuangDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, 300070, China. huangguowei@tmu.edu.cn.ORCID http://orcid.org/0000-0002-0346-6303

Funding

National Key R&D Program of China 2022YFC2010100
6 · The paper itself

Abstract

purposeAdequate micronutrients play a crucial role in cognitive health. Identifying relevant micronutrients and constructing risk prediction models can guide the prevention of mild cognitive impairment (MCI) in older adults. This study aimed to assess the associations of MCI with whole blood micronutrient levels and develop a nomogram for personalized MCI risk prediction in older adults.

methodsIn the matched case-control study, 100 MCI patients and 100 matched controls by age, sex and education from Baodi District, Tianjin, China were recruited. MCI was determined by a modified version of the Petersen criteria. Whole blood levels of 9 vitamins and 5 minerals were measured using the dried blood spot technique. Weighted quantile sum regression was employed to identify the most significant micronutrients associated with cognitive function. Receiver operating characteristic (ROC) curves were constructed, and a nomogram for predicting MCI risk was developed.

resultsHigh levels of vitamins (vitamin A, vitamin B

conclusionThe nomogram based on vitamin B

Indexed as

Cognitive DysfunctionMicronutrientsAgedAged, 80 and overCase-Control StudiesChinaEast Asian PeopleFemaleHumansMaleMiddle AgedNomogramsROC CurveSeleniumVitaminsMicronutrientsSeleniumVitaminsDried blood spotMatched case–control studyMild cognitive impairmentMulti-micronutrientsOlder adultsPrediction model

Identifiers

PMID40047966
PMCPMC11885343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.