Evidence map›Paper›PMID 40047957›Full record

ArticleEuropean journal of nutrition2025

Association of oxidative balance score with incident cardiovascular disease in patients with type 2 diabetes: findings of the UK Biobank study.

Licheng Cheng, Xuanyang Wang, Keke Dang, Jinxia Hu, Jia Zhang, Xiaoqing Xu, Sijia Pan, Xiang Qi, Ying Li

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Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Licheng Cheng *Department of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Xuanyang Wang *Department of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Keke DangDepartment of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Jinxia HuDepartment of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Jia ZhangDepartment of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Xiaoqing XuDepartment of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Sijia PanDepartment of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Xiang QiDepartment of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China.
Ying LiDepartment of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, 157 Baojian Road, Harbin, 150081, P. R. China. liying_helen@163.com.ORCID http://orcid.org/0000-0002-7595-2474

Funding

National Natural Science Foundation of China 82030100
6 · The paper itself

Abstract

BACKGROUND &

aimsTo clarify how dietary and lifestyle factors work on diabetes-related cardiovascular disease (CVD), we investigated whether the increased risk of CVD in patients with type 2 diabetes mellitus (T2DM) could be offset by an increase in diet and/or lifestyle with antioxidant potential. RESEARCH DESIGN AND

methodsA total of 7,658 individuals from UK Biobank (UKB) with T2DM but no diagnosed CVD were included in this study. We screened combinations of 16 nutrients and/or 4 lifestyles to calculate the Oxidative Balance Score (OBS), dietary OBS (DOBS), and lifestyle OBS (LOBS). Cox proportional hazards (CPH) regression models and mediation statistical models were performed.

resultsAfter adjusting for covariates, CPH regression models showed inverse associations between both OBS and LOBS and CVD. The highest tertile of LOBS was significantly associated with a lower risk of CVD compared to the lowest tertile, with hazard ratios and 95% CIs as follows: Atherosclerotic Cardiovascular Disease (ASCVD) 0.81 (0.68-0.97), Coronary Artery Disease (CAD) 0.79 (0.67-0.93), Atrial Fibrillation (AF) 0.56 (0.45-0.70) and CVD mortality 0.67(0.51-0.88). Correspondingly, the results of associations between the highest tertile of OBS and risks of CVDs above were ASCVD 0.80 (0.64-0.99), CAD 0.83(0.68-1.01), AF 0.73 (0.57-0.92) and CVD mortality 0.68 (0.50-0.92). No associations between DOBS and CVDs were observed [ASCVD 0.83 (0.66-1.05), CAD 0.86 (0.70-1.05), AF 0.77 (0.60-1.00), and CVD mortality 0.79 (0.57-1.10)]. These results were consistent in stratified analyses. Additionally, we identified a mediating role for C-reactive protein (CRP) and white blood cell count (WBC) in the observed relations, with indirect effect and mediation estimates as follows: CRP - 0.003 6.0% (OBS and CAD), -0.008 17.2%, -0.003 11.7%, and - 0.010 14.5% (OBS/DOBS/LOBS and CVD mortality); WBC - 0.006 14.3%, -0.006 12.6%, -0.006 13.4%, -0.005 23.3% (OBS and CVDs), -0.008 11.8%, -0.008 11.9%, -0.008 11.8%, and - 0.005 5.3% (LOBS and CVDs).

conclusionSustained adherence to diets and lifestyles with high antioxidant potential may significantly reduce the risk of CVD in individuals with T2DM.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2DietOxidative StressAgedAntioxidantsBiological Specimen BanksFemaleHumansIncidenceLife StyleMaleMiddle AgedProportional Hazards ModelsRisk FactorsUK BiobankAntioxidantsCardiovascular diseasesOxidative balance scoreOxidative stressType 2 diabetesUK Biobank

Identifiers

PMID40047957

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.