Evidence map›Paper›PMID 40047927›Full record

ArticleJournal of neurology2025

The deltoid muscle and the pattern of paresis in ALS.

Albert Ludolph, Veronika Klose, Jens Dreyhaupt, Kelly Del Tredici, Heiko Braak

Abstract read
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Albert LudolphDepartment of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany. albert.ludolph@rku.de.ORCID http://orcid.org/0000-0002-5401-0904
Veronika KloseGerman Center of Neurodegenerative Diseases, Ulm Site, Ulm, Germany.
Jens DreyhauptInstitute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstraße 22, 89081, Ulm, Germany.
Kelly Del TrediciClinical Neuroanatomy, Department of Neurology, Center for Biomedical Research, Ulm University, Helmholtzstraße 8/1, 89081, Ulm, Germany.
Heiko BraakClinical Neuroanatomy, Department of Neurology, Center for Biomedical Research, Ulm University, Helmholtzstraße 8/1, 89081, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is neuroanatomical and clinical evidence that the corticospinal tract governs the patterns of pareses in sporadic ALS. These patterns are mirrored by phylogenetically young monosynaptic corticomotor neuronal connections. It is well known that, clinically, dysfunction of the deltoid muscle contributes considerably to the early disability of the ALS patient. In this study, we prospectively compared the degree of pareses of the deltoid muscle with the triceps and biceps brachii in N = 71 patients (426 muscles). We could show that the extent of involvement of the deltoid muscle early in the disease process resembles that of the biceps rather than the triceps brachii. This pattern is consistent with functional data of the corticospinal monosynaptic connectivity of all three muscles.

Indexed as

Amyotrophic Lateral SclerosisDeltoid MuscleMuscle, SkeletalParesisAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesPyramidal TractsAmyotrophic lateral sclerosisBicepsCorticomotorneuronalDeltoidMonosynpaticPattern of paresis

Identifiers

PMID40047927
PMCPMC11885358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.