Evidence map›Paper›PMID 40047858›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Natural compounds as regulators of miRNAs: exploring a new avenue for treating brain cancer.

Ahmed S Doghish, Walaa A El-Dakroury, Ahmed I Abulsoud, Nourhan M Abdelmaksoud, Shaza H Aly, Abdullah M M Elbadry, Osama A Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Nehal I Rizk and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt. ahmed_doghish@azhar.edu.eg.ORCID 0000-0002-0136-7096
Walaa A El-DakrouryDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Ahmed I AbulsoudBiochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt.
Nourhan M AbdelmaksoudDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt.
Shaza H AlyDepartment of Pharmacognosy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Abdullah M M ElbadryBadr University in Cairo Research Center, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia.
Mustafa Ahmed Abdel-ReheimDepartment of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia. m.ahmed@su.edu.sa.ORCID 0000-0002-7728-0923
Mohamed Bakr ZakiDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, Menoufia, 32897, Egypt.
Nehal I RizkDepartment of Biochemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo, 11786, Egypt.
Esraa M MosalamBiochemistry Department, Faculty of Pharmacy, Menoufia University, Shebin El-Kom, 32511, Egypt.
Amany S El-KhoulyDepartment of Chemistry, College of Science, King Faisal University, Al-Ahsa, P.O. Box 380, Hofuf, 31982, Saudi Arabia.
Sherif S Abdel MageedPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying natural substances that regulate microRNAs (miRNAs) has facilitated the development of innovative therapeutic strategies for brain cancer therapy. This work investigates the intricate interaction between miRNA expression and the specified chemicals, aiming to comprehend how natural compounds may modify miRNA profiles to affect carcinogenic pathways. Curcumin and resveratrol are natural compounds that have lately shown anticancer effects. These drugs function by modifying the expression of certain miRNAs linked to tumor proliferation and treatment resistance. Natural therapies can target these miRNAs, potentially improving therapy effectiveness and mitigating the adverse effects often linked to conventional pharmaceuticals. This review collects the latest findings on the impact of natural compounds on miRNAs. It presents an innovative approach to brain cancer treatment by leveraging the bioactivity of these substances to reinstate normal miRNA function. Natural chemicals provide a comprehensive strategy for addressing brain cancer, underscoring their significance in transforming future therapeutics. From this perspective, natural compounds provide a means to combat brain cancer.

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicBiological ProductsBrain NeoplasmsMicroRNAsAnimalsCurcuminGene Expression Regulation, NeoplasticHumansResveratrolAntineoplastic AgentsAntineoplastic Agents, PhytogenicBiological ProductsCurcuminMicroRNAsResveratrolBiogenesisBrain cancerMicroRNAsNanoparticlesNatural productsSignaling

Identifiers

PMID40047858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.