Evidence map›Paper›PMID 40047853›Full record

Trial reportJournal of anesthesia2025

Comparison of the postoperative analgesic efficacy of the ultrasound-guided erector spinae plane block and intrathecal morphine in patients undergoing total abdominal hysterectomy under general anesthesia: a randomized controlled trial.

Tarek Mohamed Ashoor, Ibrahim Mamdouh Esmat, Mohammad Abdalsalam Algendy, Noha Refaat Mohamed, Sahar Mohamed Talaat, Amal Hamed Rabie, Ahmed Mohammed Elsayed

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of anesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05218733 (Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05218733 phase4completednot on this map

Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy: A Randomized Controlled Comparison Between Ultrasound Guided Erector Spinae Plane Block and Intrathecal Morphine

TypeinterventionalSponsorAin Shams UniversityRan2022 to 2023Enrolled120ConditionsPost Operative PainArmsUltrasound Guided Erector Spinae Plane Block, Intra thecal morphine., General anesthesia using intravenous fentanyl (1µgm/kg)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tarek Mohamed AshoorDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Ibrahim Mamdouh EsmatDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain-Shams University, Cairo, Egypt. Ibrahim_mamdouh@med.asu.edu.eg.ORCID http://orcid.org/0000-0003-3456-0471
Mohammad Abdalsalam AlgendyDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Noha Refaat MohamedDepartment of Clinical Pathology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Sahar Mohamed TalaatDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Amal Hamed RabieDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Ahmed Mohammed ElsayedDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTotal abdominal hysterectomy (TAH) is a common surgical procedure. Erector spinae plane block (ESPB) and intrathecal morphine (ITM) provide adequate postoperative (PO) analgesia. However, ITM side effects may limit its use. Researchers investigated the efficacy of bilateral ultrasound-guided ESPB on PO pain and analgesic consumption compared to ITM in the first 24 h following TAH under general anesthesia.

methods120 patients premedicated with 3 mg intravenous granisetron were randomized into three equal groups: bilateral ultrasound-guided ESPB, ITM or control group. The primary outcome of this study was the time to first request for a rescue analgesic (tramadol).

resultsCompared to the control group, the ESPB and ITM groups showed higher time to first request for a rescue analgesic and lower total tramadol consumption 24 h following surgery (P < 0.001) with significant differences between the ESPB and ITM groups (P < 0.001). The ITM group showed lower pain scores and lower readings of both serum glucose and cortisol levels compared to the other two groups 24 h after surgery (P < 0.001). The ITM group also had higher incidences of nausea and pruritus 24 h after surgery (P < 0.001). The use of a single intrathecal injection of 0.3 mg morphine did not show any respiratory depression.

conclusion0.3 mg intrathecal morphine was superior to erector spinae plane block for postoperative pain relief, 24 h after surgery, regarding attenuated stress response, lower pain scores at rest and on coughing and lower tramadol consumption. IRB: IRB 00006379//31-1-2022. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Identifier: NCT05218733.

Indexed as

Analgesics, OpioidAnesthesia, GeneralHysterectomyMorphineNerve BlockPostoperative PainUltrasonography, InterventionalAdultFemaleHumansInjections, SpinalMiddle AgedPain MeasurementParaspinal MusclesAnalgesics, OpioidMorphineAnalgesiaErector spinae plane blockGeneral anesthesiaIntrathecal morphinePainPostoperativeTotal abdominal hysterectomyUltrasound

Identifiers

PMID40047853
PMCPMC11937175

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.