ArticleAnimal science journal = Nihon chikusan Gakkaiho
Interleukin 1 Receptor Antagonist (IL-1ra) Production and Expression Dynamics in Mammary Glands After Lipopolysaccharide Infusion.
Article in Animal science journal = Nihon chikusan Gakkaiho. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Mammary leukocytes function of endotoxin tolerant goat induced by intrauterine infusion of lipopolysaccharide.Innate immunityArticle
- Serum Amyloid A and Lactoferrin Concentrations in Milk at Mastitis Diagnosis Can Serve as a Predictive Indicators of Intramammary Status 7 Days Later.Animal science journal = Nihon chikusan GakkaihoArticle
- Changes in Antimicrobial Component Concentrations in Goat Milk Following Intramammary Lipopolysaccharide Administration.Animal science journal = Nihon chikusan GakkaihoArticle
- Effects of Osmotic and Hydrostatic Pressures on Milk and Antimicrobial Substance Production in Lactating Goats.Animal science journal = Nihon chikusan GakkaihoArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Interleukin-1 receptor antagonist (IL-1ra) is an anti-inflammatory cytokine, whose balance with pro-inflammatory cytokines affects the susceptibility to and severity of udder mastitis. In this study, we aimed to investigate the IL-1ra dynamics in the mammary gland immune system. Lipopolysaccharide (LPS group) or saline (control group) were infused into mammary gland of goats. Milk samples were collected 0-72 h after intramammary infusion. The results indicated that LPS infusion increased the somatic cell count and serum amyloid A level in milk, compared to those in the control group. The IL-1ra concentration in milk decreased after LPS infusion and was significantly lower at 4 h in the LPS group compared to that in the control group. The number of IL-1ra-positive cells significantly increased from 8 to 12 h in the LPS group. Immunohistochemistry revealed IL-1ra-positive cells in the alveolar connective tissue. Notably, the number of phagocytic cells and IL-1ra mRNA expression did not change significantly after LPS infusion. Overall, these results suggest that IL-1ra mRNA is expressed and synthesized in leukocytes, but is not secreted into milk for at least 72 h after intramammary LPS infusion. Furthermore, these findings highlight the role of IL-1ra in controlling inflammation in the mammary glands.
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Registered trials
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