ArticleEpilepsia2025
Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity.Epilepsia open · 2026Review
- Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Integrating rare and common variation in epilepsy genetics: from genetic architecture to penetrance and clinical expressivity.Frontiers in genetics · 2026Review
- Genomics and epilepsy: Opportunities to improve understanding and management.Developmental medicine and child neurology · 2026Review
- Phenotypic heterogeneity in familial epilepsies is influenced by polygenic risk for generalized and focal epilepsies.Epilepsia · 2025Article
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6 authors.
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Abstract
objectiveAlthough previous research shows that generalized and focal epilepsies have at least some distinct genetic influences, it remains uncertain why some families manifest both types of epilepsy. We tested two hypotheses: (1) families with both generalized and focal epilepsy carry separate risk alleles for both types; and (2) within mixed families, the type of epilepsy each individual manifests is influenced by the relative burden of separate risk alleles for generalized epilepsies and focal epilepsies.
methodsThe Epi4K cohort included 711 individuals with epilepsy from 257 families (113 generalized families, 66 focal families, 78 mixed families). We calculated polygenic risk scores (PRSs) for genetic generalized epilepsy (GGE_PRS) and for focal epilepsy (Focal_PRS). We used mixed-effects models to compare these PRSs between and within families, accounting for relatedness.
resultsCompared to population controls, individuals in generalized families had elevated GGE_PRS (p < .001) but not elevated Focal_PRS (p = .50); focal family individuals had elevated Focal_PRS (p = .008) but not elevated GGE_PRS (p = .22); and individuals in mixed families had both elevated GGE_PRS and elevated Focal_PRS (both p < .001). Within mixed families, GGE_PRS was higher in individuals with generalized epilepsy than in individuals with focal epilepsy (p < .001), whereas we did not detect a difference in Focal_PRS between individuals with generalized and focal epilepsy (p = .46). The GGE_PRS value explained 10% of the variance in phenotype within mixed families. SIGNIFICANCE: The occurrence of families with both generalized and focal epilepsy in separate individuals is explained at least partly by the chance co-occurrence of distinct genetic risk alleles for generalized and focal epilepsies. Within mixed families, an individual's epilepsy type can be explained at least in part by the relative burden of risk alleles for genetic generalized epilepsy.
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