ArticleBiochemistry2025
Crystal Structure, Modeling, and Identification of Key Residues Provide Insights into the Mechanism of the Key Toxoflavin Biosynthesis Protein ToxD.
Savannah F Justen, Michael K Fenwick, Kyle K Axt, James A Cherry, Steven E Ealick, Benjamin Philmus
Abstract read
In one paragraphArticle in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
6 authors.
Savannah F JustenDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Michael K FenwickDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0001-5066-4962 Kyle K AxtDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
James A CherryDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Steven E EalickDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.ORCID 0000-0001-8548-112X Benjamin PhilmusDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2085-0873 Funding
Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3MOverall (pp. 40-62)P41GM103485 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2012 to 2018
$15.5MOverall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3MStructural Studies of Enzymes of Thiamin BiosynthesisR01DK067081 · NIDDK · CORNELL UNIVERSITY ITHACA · PI EALICK, STEVEN E · 2005 to 2017
$4.2MStructural Biology of Purine and Pyrimidine Biosynthesis and MetabolismR01GM073220 · NIGMS · CORNELL UNIVERSITY ITHACA · PI EALICK, STEVEN E · 2005 to 2012
$2.4MNIDDK NIH HHS R01 DK067081NIGMS NIH HHS P30 GM124166NIGMS NIH HHS P41 GM103403NIGMS NIH HHS P41 GM103485NIGMS NIH HHS R01 GM073220
6 · The paper itselfAbstract
Toxoflavin, a toxic secondary metabolite produced by a variety of bacteria, has been implicated as a causative agent in food poisoning and a virulence factor in phytopathogenic bacteria. This toxin is produced by genes encoded in the
Indexed as
Bacterial ProteinsPyrimidinonesTriazinesAmino Acid SequenceBurkholderiaCatalytic DomainCrystallography, X-RayModels, MolecularMutagenesis, Site-DirectedProtein ConformationPseudomonasBacterial ProteinsPyrimidinonestoxoflavinTriazines
Identifiers
PMID40047534
PMCPMC11989309
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