Evidence map›Paper›PMID 40047437›Full record

ArticleJournal of virology2025

HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function.

Lingxi Qiu, Xuedi Gao, Xinyue Shao, Jingwen Xi, Siyang Chen, Thanh Pham, Yi Wang, Jonathan Dong, Samhita Divakar Rao, Jingting Hao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lingxi Qiu *Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0009-0005-3377-068X
Xuedi Gao *Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Xinyue ShaoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jingwen XiDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Siyang ChenDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Thanh PhamDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-8959-7947
Yi WangDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jonathan DongDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Samhita Divakar RaoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jingting HaoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jae Ho LoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Rirong YangDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Esteban A EngelPrinceton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0003-1115-9474
Colin M CrumpDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9918-9998
Weiming YuanDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-4780-7157

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Zika Virus Capsid Protein Mediated Blockage of host microRNA machineryR01NS110687 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2019 to 2023
$2.2M
Herpes simplex virus-1 evasion of CD1d antigen presentation pathwayR01AI091987 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, WEIMING · 2012 to 2016
$2.0M
cGAS-STING mediated neuroinflammation in Alzheimer's diseaseR56AG082361 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, WEIMING, ZHAO, ZHEN · 2023 to 2023
$826k
Suppression of KIF3A function by herpes simplex virus-1 US3 kinase for immune evasionR21AI149365 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, WEIMING · 2020 to 2021
$454k
NCI NIH HHS P30 CA014089NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI091987NIAID NIH HHS R21 AI149365NIA NIH HHS R56 AG082361NIDA NIH HHS 75N95020D00005NIH HHS P40 OD010996NINDS NIH HHS R01 NS110687ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Herpesviruses, including α-herpesvirus and herpes simplex virus (HSV-1), are masters of immune evasion. Previously we demonstrated that CD1d-restricted NKT cells are required for optimal anti-HSV-1 immune responses and HSV-1 efficiently downregulates CD1d to suppress NKT cell function. To delineate how the virus evades NKT cell function and establishes infection IMPORTANCE: In the large DNA genomes of herpeviruses, there are many genes encoding associate proteins. Most of these proteins are not essential for viral replication but play key roles in viral pathogenesis, in particular, modulating the host immune system to allow efficient viral replication

Indexed as

Antigens, CD1dHerpesvirus 1, HumanNatural Killer T-CellsNedd4 Ubiquitin Protein LigasesViral ProteinsAnimalsDown-RegulationHerpes SimplexHumansImmune EvasionMiceMice, Inbred C57BLUbiquitinationAntigens, CD1dCD1D protein, humanNedd4 Ubiquitin Protein LigasesViral ProteinsCD1dherpesvirusesimmune evasionNedd4LNKTUL56viral pathogenesis

Identifiers

PMID40047437
PMCPMC11998485

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.