Evidence map›Paper›PMID 40047413›Full record

ArticlemBio2025

3D meshwork architecture of the outer coat protein CotE: implications for bacterial endospore sporulation and germination.

Dukwon Lee, Yeongjin Baek, Migak Park, Doyeon Kim, Kyumi Byun, Jaekyung Hyun, Nam-Chul Ha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dukwon LeeDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Center for Food and Bioconvergence, Interdisciplinary Programs in Agricultural Genomics, CALS, Seoul National University, Seoul, South Korea.ORCID 0000-0003-2733-1953
Yeongjin BaekDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Center for Food and Bioconvergence, Interdisciplinary Programs in Agricultural Genomics, CALS, Seoul National University, Seoul, South Korea.
Migak ParkDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Center for Food and Bioconvergence, Interdisciplinary Programs in Agricultural Genomics, CALS, Seoul National University, Seoul, South Korea.
Doyeon KimDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Center for Food and Bioconvergence, Interdisciplinary Programs in Agricultural Genomics, CALS, Seoul National University, Seoul, South Korea.
Kyumi ByunSchool of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.
Jaekyung HyunSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
Nam-Chul HaDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Center for Food and Bioconvergence, Interdisciplinary Programs in Agricultural Genomics, CALS, Seoul National University, Seoul, South Korea.ORCID 0000-0003-4813-748X

Funding

Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (iPET) 321036054HD020National Research Foundation of Korea (NRF) 2022R1A2C109178313
6 · The paper itself

Abstract

IMPORTANCE: Bacterial endospores are highly resilient structures that allow bacteria to survive extreme environmental conditions, making them a significant concern in food safety and healthcare. The protein CotE plays a critical role in forming the protective outer coat of these endospores. Our research uncovers the three-dimensional meshwork architecture of CotE and reveals how it contributes to the structural integrity and rapid disassembly of endospores during germination. By understanding CotE's unique 3D structure and its interaction with other molecules, we gain valuable insights into how bacterial endospores are formed and how they can be effectively targeted for sterilization. This work not only advances our fundamental knowledge of bacterial endospore biology but also has potential applications in developing new strategies to combat bacterial contamination and improve sterilization techniques in the food and healthcare industries.

Indexed as

Bacillus cereusBacterial ProteinsSpores, BacterialCalciumCryoelectron MicroscopyPicolinic AcidsProtein ConformationProtein MultimerizationBacterial ProteinsCalciumdipicolinic acidPicolinic AcidsBacillus cereusCotEcryo-electron microscopycryo-electron tomographyendospore

Identifiers

PMID40047413
PMCPMC11980541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.