Evidence map›Paper›PMID 40047394›Full record

ArticleThe Journal of physiology2025

The apical mucus layer alters the pharmacological properties of the airway epithelium.

Daniela Guidone, Martina de Santis, Emanuela Pesce, Valeria Capurro, Nicoletta Pedemonte, Luis J V Galietta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniela GuidoneTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.ORCID 0000-0002-9301-8095
Martina de SantisTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.ORCID 0009-0007-8185-6490
Emanuela PesceUOC Genetica Medica, Istituto Giannina Gaslini, Genova, Italy.
Valeria CapurroUOC Genetica Medica, Istituto Giannina Gaslini, Genova, Italy.
Nicoletta PedemonteUOC Genetica Medica, Istituto Giannina Gaslini, Genova, Italy.ORCID 0000-0002-5161-1720
Luis J V GaliettaTelethon Institute of Genetics and Medicine, Pozzuoli, Italy.ORCID 0000-0001-8686-3461

Funding

Cystic Fibrosis Foundation (CFF) GALIET22I0Italian Foundation for Cystic Fibrosis FFC#9/2022Italian Foundation for Cystic Fibrosis GMRF#1/2024Ministero della Salute (Italy Ministry of Health) GR-2018-12367126
6 · The paper itself

Abstract

Electrogenic transepithelial ion transport can be measured with the short-circuit current technique. Such experiments are frequently used to evaluate the activity of the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel that is defective in cystic fibrosis, one of the most frequent genetic diseases. Typically, CFTR activity is estimated from the effect of CFTR

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorMucusRespiratory MucosaBenzoatesCell LineDithiothreitolHumansThiazolidines3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinoneBenzoatesCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorDithiothreitolThiazolidinesairway epitheliumchannel blockerchloride channelcystic fibrosis transmembrane conductance regulatormucus

Identifiers

PMID40047394
PMCPMC12072236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.