Evidence map›Paper›PMID 40047386›Full record

ArticleActa dermato-venereologica2025

Definition of the Concept of Super-responders in Atopic Dermatitis: A Spanish Delphi Consensus.

Juan-Manuel Liñán-Barroso, Juan-Carlos Hernández-Rodríguez, Ricardo Ruiz-Villaverde, Manuel Galán Gutiérrez, Francisco Navarro-Triviño, Javier Domínguez Cruz, José-Carlos Armario-Hita, Jose-Juan Pereyra-Rodriguez

Abstract readConsensus Statement
In one paragraph

Article in Acta dermato-venereologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Memory Cells in Atopic Dermatitis: Paving the Way to Disease Modification.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan-Manuel Liñán-BarrosoDepartment of Dermatology, Virgen del Rocío University Hospital, Sevilla, Spain.
Juan-Carlos Hernández-RodríguezDepartment of Dermatology, Virgen del Rocío University Hospital, Sevilla, Spain. j.carlos.her.rod@gmail.com.ORCID 0000-0003-2525-4069
Ricardo Ruiz-VillaverdeDepartment of Dermatology, Clínico San Cecilio University Hospital, Granada, Spain.ORCID 0000-0002-0381-6174
Manuel Galán GutiérrezDepartment of Dermatology, Reina Sofía University Hospital, Córdoba, Spain.ORCID 0000-0002-3496-3572
Francisco Navarro-TriviñoDepartment of Dermatology, Clínico San Cecilio University Hospital, Granada, Spain.
Javier Domínguez CruzDepartment of Dermatology, Virgen del Rocío University Hospital, Sevilla, Spain.
José-Carlos Armario-HitaDepartment of Dermatology, Puerto Real University Hospital, Puerto Real, Cádiz, Spain.ORCID 0000-0002-9919-0486
Jose-Juan Pereyra-RodriguezDepartment of Dermatology, Virgen del Rocío University Hospital, Sevilla, Spain; Department of Medicine, School of Medicine, University of Sevilla, Sevilla, Spain.ORCID 0000-0001-6843-5877

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A consensus study of experts was conducted to establish a definition of the concept of super-responders (SR) in atopic dermatitis (AD). The study employed a Delphi methodology based on 2 rounds to define the concept of SR in AD, exploring the opinions of expert dermatologists in AD from across Spain regarding a series of statements developed after a systematic review. Consensus was predefined as an agreement of ≥ 80% among all respondents. In the first round, 4 statements reached consensus. In the second round, 2 additional statements reached consensus. To illustrate these definitions, a set of practical cases was provided, and the level of agreement among experts was evaluated. According to the agreed statements, time is important when defining the achievable response as SR. The concept of SR should associate a rapid response (before week 16), include both symptom variables, such as the Eczema Area and Severity Index and Investigators Global Assessment (IGA) and patient-reported outcomes, including pruritus or the Patient-Oriented Eczema Measure. This concept should be associated with complete or nearly complete clearance of lesions (IGA 0-1), and with sustained responses over time (at week 52). Mild flares (IGA ≤ 2) may occur without varying according to the patient's age.

Indexed as

Dermatitis, AtopicDermatologic AgentsTerminology as TopicAdultDelphi TechniqueFemaleHumansMalePatient Reported Outcome MeasuresSeverity of Illness IndexSpainTime FactorsTreatment OutcomeDermatologic Agents

Identifiers

PMID40047386
PMCPMC11898106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.