Evidence map›Paper›PMID 40047349›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2025

Risk of Cytomegalovirus Viremia Following Transplantation of Hepatitis C-Viremic Donor Kidneys Into Uninfected Recipients: A Multi-Center Retrospective Cohort Study.

Vishnu S Potluri, David Goldberg, Siqi Zhang, Douglas E Schaubel, Miklos Z Molnar, Rachel Forbes, Megan E Sise, James L Rogers, Vasanthi Balaraman, Anshul Bhalla and 12 more

Abstract read
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In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Vishnu S PotluriRenal-Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David GoldbergDivision of Digestive Health and Liver Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Siqi ZhangCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Douglas E SchaubelDepartment of Biostatistics, Epidemiology and Bioinformatics, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Miklos Z MolnarDepartment of Internal Medicine, Division of Nephrology & Hypertension, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, Utah, USA.
Rachel ForbesDepartment of Surgery, Division of Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-6827-791X
Megan E SiseDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
James L RogersDepartment of Surgery, Division of Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vasanthi BalaramanDivision of Transplant Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Anshul BhallaDepartment of Nephrology, Kaiser Permanente, San Francisco, California, USA.
David ShafferDepartment of Surgery, Division of Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Beatrice P ConcepcionSection of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Raymond T ChungDepartment of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ian A StrohbehnDepartment of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Shristi MapchanRenal-Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Vikas VujjiniNephrology Associates, Conway, Arkansas, USA.
Akhila SangadiDivision of Digestive Health and Liver Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Eric MartinDivision of Digestive Health and Liver Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Roy D BloomRenal-Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alyssa AmmazzalorsoDivision of Infectious Disease, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Emily A BlumbergDivision of Infectious Disease, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5193-6170
Peter P ReeseDepartment of Surgery, Division of Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-1440-069X

Funding

Survival Analysis Methods for Organ Failure DataR01DK070869 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS EARL SCHAUBEL · 2005 to 2026
$4.7M
Impact of Geographic Boundaries on Deceased Donor Kidney Discard, Allocation, and OutcomesK08DK127250 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI POTLURI, VISHNU SAGAR · 2021 to 2025
$838k
Mentored research in solid organ transplantation: outcomes using organs from Hepatitis C virus infected donors for uninfected recipientsK24AI146137 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI REESE, PETER PHILIP · 2019 to 2023
$671k
NIAID NIH HHS K24 AI146137NIDDK NIH HHS K08 DK127250NIDDK NIH HHS R01 DK070869NIH HHSNIH HHS K08 DK127250NIH HHS K24-AI146137NIH HHS R01DK070869
6 · The paper itself

Abstract

backgroundSeveral studies have suggested an increased risk of cytomegalovirus (CMV) viremia among Hepatitis C virus (HCV)-uninfected recipients of kidney transplants from HCV-RNA+ deceased donors (HCV D+/R-), but these studies featured small sample sizes and limited ability to address confounding variables.

methodsWe assembled a retrospective cohort of adult kidney transplant recipients at five US centers between 4/1/2015 and 12/31/2020 to determine the association between HCV D+/R- transplants and the outcomes of CMV viremia (> 1000 IU/mL), death-censored graft failure, and mortality in the first posttransplant year compared to HCV D-/R- transplants. We generated highly similar matched cohorts of HCV D+/R- and HCV D-/R- recipients based on attributes that affect the risk of CMV viremia. We matched exactly on center, CMV donor/recipient serostatus, and antibody induction therapy.

resultsThe cohort comprised 275 HCV D+/R- recipients with a mean age of 52.5 years (SD = 10.7); 19% were CMV D+/R-, and 74% received anti-thymocyte globulin induction. With variable ratio matching, 267 HCV D+/R- recipients were matched to 996 HCV D-/R- recipients. CMV viremia occurred in 15% of HCV D+/R- and 11% of HCV D-R- recipients. In Cox regression, transplantation with an HCV-RNA+ donor kidney was not associated with a significantly higher risk of CMV viremia (HR 1.3, 95% CI 0.89-1.92) or death-censored graft loss (HR 0.61, 95% CI 0.31-1.2).

conclusionThe risk of CMV viremia was not significantly increased among HCV D+/R- kidney recipients. Future studies should examine associations between donor-derived HCV infection and clinical outcomes of CMV syndrome and disease.

Indexed as

cytomegalovirusepidemiologyhepatitis c viruskidney transplant

Identifiers

PMID40047349
PMCPMC12205285

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